Relevant conflict of interest: Nothing to report. This study was financially supported by Diagnostic Molecular Imaging (DIMI), Sixth European Program, project No: LSHB-CT-2005-512146 and the ItalianMinistry of Health, COFIN project (N. 2004062394_002 and N. 2006068233_003).
In vivo evidence for GABAA receptor changes in the sensorimotor system in primary dystonia†
Article first published online: 2 MAR 2011
Copyright © 2011 Movement Disorder Society
Volume 26, Issue 5, pages 852–857, April 2011
How to Cite
Garibotto, V., Romito, L. M., Elia, A. E., Soliveri, P., Panzacchi, A., Carpinelli, A., Tinazzi, M., Albanese, A. and Perani, D. (2011), In vivo evidence for GABAA receptor changes in the sensorimotor system in primary dystonia. Mov. Disord., 26: 852–857. doi: 10.1002/mds.23553
- Issue published online: 21 APR 2011
- Article first published online: 2 MAR 2011
- Manuscript Accepted: 1 NOV 2010
- Manuscript Revised: 5 OCT 2010
- Manuscript Received: 19 MAY 2010
- GABAA receptors;
- sensorimotor cortex;
Preclinical and clinical evidence suggests that impaired gamma-aminobutyric (GABA) control, leading to disinhibition within the sensorimotor system, might play a role in dystonia. Aim of this study is the in vivo assessment of the GABAergic system in dystonia using positron emission tomography (PET) and 11C-flumazenil, a selective GABAA receptor ligand.
Fourteen subjects with primary dystonia (9 carriers of the DYT1 mutation and 5 sporadic cases) were compared to 11 controls, using a simplified reference tissue model to measure binding potential.
Voxel-based analyses showed a reduction in GABAA receptor expression/affinity both in DYT1 carriers and sporadic patients in primary motor and premotor cortex, primary and secondary somatosensory cortex, and in the motor component of the cingulate gyrus.
Dysfunction of GABAA receptors in sensorimotor systems in primary (genetic and sporadic) dystonia supports the view that lack of GABAergic control may be associated with the generation of dystonic movements. © 2011 Movement Disorder Society