Relevant conflict of interest/financial disclosures: Nothing to report. This work was supported by the Reta Lila Weston Trust.
Decades of delayed diagnosis in 4 levodopa-responsive young-onset monogenetic parkinsonism patients†
Article first published online: 29 MAR 2011
Copyright © 2011 Movement Disorder Society
Volume 26, Issue 7, pages 1337–1340, June 2011
How to Cite
Ling, H., Braschinsky, M., Taba, P., Lüüs, S.-M., Doherty, K., Hotter, A., Poewe, W. and Lees, A. J. (2011), Decades of delayed diagnosis in 4 levodopa-responsive young-onset monogenetic parkinsonism patients. Mov. Disord., 26: 1337–1340. doi: 10.1002/mds.23563
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 20 JUN 2011
- Article first published online: 29 MAR 2011
- Manuscript Accepted: 8 NOV 2010
- Manuscript Revised: 1 NOV 2010
- Manuscript Received: 12 SEP 2010
- monogenetic parkinsonism;
- psychogenic movement disorders;
- conversion disorder;
- chronic fatigue syndrome
We report 4 patients with young-onset monogenetic parkinsonism, each of whom was misdiagnosed with either a psychogenic movement disorder or chronic fatigue syndrome for 10 to 23 years after the onset of their first symptoms.
Once the diagnosis was eventually made, they all had a rapid and excellent response to levodopa, albeit with the early appearance of interdose dyskinesias in 3.
We discuss possible reasons for the missed diagnosis despite the relentless progression of their motor handicap. DAT scanning supported the revised clinical diagnosis of parkinsonism. © 2011 Movement Disorder Society