Relevant conflict of interest: Nothing to report.
Prevalence of Small Intestinal Bacterial Overgrowth in Parkinson's Disease†
Article first published online: 1 FEB 2011
Copyright © 2011 Movement Disorder Society
Volume 26, Issue 5, pages 889–892, April 2011
How to Cite
Gabrielli, M., Bonazzi, P., Scarpellini, E., Bendia, E., Lauritano, E. C., Fasano, A., Ceravolo, M. G., Capecci, M., Rita Bentivoglio, A., Provinciali, L., Tonali, P. A. and Gasbarrini, A. (2011), Prevalence of Small Intestinal Bacterial Overgrowth in Parkinson's Disease. Mov. Disord., 26: 889–892. doi: 10.1002/mds.23566
- Issue published online: 21 APR 2011
- Article first published online: 1 FEB 2011
- Manuscript Accepted: 8 NOV 2010
- Manuscript Revised: 1 NOV 2010
- Manuscript Received: 4 JUN 2010
- small intestinal bacterial overgrowth;
- gut flora;
- Parkinson's disease;
- glucose breath test
Parkinson's disease (PD) is associated with gastrointestinal motility abnormalities that could favor the occurrence of small intestinal bacterial overgrowth. The aim of the study was to assess the prevalence of small intestinal bacterial overgrowth in PD patients.
Consecutive PD patients were enrolled. The controls were subjects without PD. All patients and controls underwent the glucose breath test to assess small intestinal bacterial overgrowth.
Forty-eight PD patients and 36 controls were enrolled. The prevalence of small intestinal bacterial overgrowth was significantly higher in PD patients than in controls (54.17% vs 8.33%; P < .0001; OR, 2.24; 95% CI, 3.50–48.24). Multivariate analysis showed Hoehn and Yahr stage (OR, 3.07; 95% CI, 1.14–8.27) and Unified PD Rating score (OR, 1.12; 95% CI, 1.02–1.23) were significantly associated with small intestinal bacterial overgrowth in PD patients.
Small intestinal bacterial overgrowth is highly prevalent in PD. Gastrointestinal motility abnormalities might explain this association. © 2011 Movement Disorder Society