Milestones in tremor research

Authors

  • Rodger Elble MD, PhD,

    1. Department of Neurology, Southern Illinois University School of Medicine, Springfield, Illinois, USA
    2. Department of Neurology, Christian-Albrechts-University, Kiel, Germany
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  • Günther Deuschl MD, PhD

    Corresponding author
    1. Department of Neurology, Christian-Albrechts-University, Kiel, Germany
    • Department of Neurology, Christian-Albrechts-University, University-Hospital Schleswig-Holstein, Campus Kiel, Schittenhelmstr. 10, 24105 Kiel, Germany
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  • Funding agencies: This study was supported by the German Research Council, SFB 855.

    Relevant conflicts of interest/financial disclosures: Nothing to report.

    Rodger Elble served as a consultant for Cleveland Medical Devices and APDM Inc. and receives grant support from the National Institute of Neurological Disorders and Stroke, GlaxoSmithKline, Pfizer, and the Kiwanis International Spastic Research Foundation. Günther Deuschl has received lecture fees from Orion, Lundbeck, Teva, and Pfizer and has been serving as a consultant for Teva. He received royalties from Thieme publishers. He is a government employee and through his institution receives funding for his research from the German Research Council, the German Ministery of Education and Health, and Medtronic.

    Full financial disclosures and author roles may be found in the online version of this article.

Abstract

Tremor is one of the most frequent movement disorders and covers a wide spectrum of entities summarized in the 1998 consensus statement of the Movement Disorder Society. Essential tremor and Parkinson tremor are most common and are also the most thoroughly studied. Major progress has occurred in the clinical semiology, neuroimaging, epidemiology, and pathophysiology of tremors. Pathology and genetic research are rapidly growing fields of study. Recently described tremor entities include orthostatic tremor, dystonic tremor, cortical tremor, and thalamic tremor. Treatment research methodology has improved substantially, but few double-blind controlled trials have been published. Deep brain stimulation is the most effective treatment for most tremors but is reserved for advanced cases. © 2011 Movement Disorder Society

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