Relevant conflict of interest/financial disclosures: Nothing to report. Full financial disclosures and author roles may be found in the online version of this article. This project was supported by the Deutsche Forschungsgemeinschaft (HO2402/6-1), the Willy Robert Pitzer Foundation (77/06), the German Federal Ministry for Education and Research (01 GI 9901), and the von behring∥rö ntgen∥stiftung (56-0039).
Hypodipsia discriminates progressive supranuclear palsy from other parkinsonian syndromes†
Article first published online: 7 MAR 2011
Copyright © 2011 Movement Disorder Society
Volume 26, Issue 5, pages 901–905, April 2011
How to Cite
Stamelou, M., Christ, H., Reuss, A., Oertel, W. and Höglinger, G. (2011), Hypodipsia discriminates progressive supranuclear palsy from other parkinsonian syndromes. Mov. Disord., 26: 901–905. doi: 10.1002/mds.23587
- Issue published online: 21 APR 2011
- Article first published online: 7 MAR 2011
- Manuscript Accepted: 17 NOV 2010
- Manuscript Revised: 15 NOV 2010
- Manuscript Received: 9 JUL 2010
- progressive supranuclear palsy;
- multiple system atrophy;
- Parkinson's disease
The objective of this study was to evaluate whether the sensation of thirst differs between patients with progressive supranuclear palsy (PSP), multiple system atrophy with predominant parkinsonism (MSA-P), and Parkinson's disease (PD).
We administered a standardized thirst questionnaire to age-, sex-, and stage-matched patients with probable PSP, PD, and MSA-P and healthy controls (HC), n = 15/group. In an independent cohort (n = 10/group), we provoked thirst by infusing hypertonic NaCl in age-, sex-, and stage-matched patients with PSP, PD, and MSA-P and recorded plasma osmolality and thirst (visual analog scale).
On questioning, 73% of PSP patients reported a reduced sensation of thirst (hypodipsia) compared with previous years (HC, 0%; PD, 7%; MSA-P, 7%; P < .0001). On NaCl infusion, PSP patients reported significantly lower thirst than did PD and MSA-P patients for all times from 20 to 95 minutes (P < .05). The thirst score at 25 minutes discriminated individual PSP patients well from PD and MSA-P patients.
Hypodipsia appears helpful in differentiating PSP from PD and MSA-P. © 2011 Movement Disorder Society