Relevant conflicts of interest/financial disclosures: Nothing to report.
Osteopontin polymorphic susceptibility factor for Parkinson's disease among patients with Gaucher disease†
Article first published online: 5 APR 2011
Copyright © 2011 Movement Disorder Society
Volume 26, Issue 7, pages 1341–1343, June 2011
How to Cite
Ribner, A., Altarescu, G., Zimran, A. and Elstein, D. (2011), Osteopontin polymorphic susceptibility factor for Parkinson's disease among patients with Gaucher disease. Mov. Disord., 26: 1341–1343. doi: 10.1002/mds.23595
Full financial disclosures and author roles can be found in the online version of this article.
- Issue published online: 20 JUN 2011
- Article first published online: 5 APR 2011
- Manuscript Accepted: 22 NOV 2010
- Manuscript Revised: 11 NOV 2010
- Manuscript Received: 2 AUG 2010
- Parkinson's disease;
- Gaucher disease;
- polymorphic variants
There is an increased incidence of Parkinson's disease among obligate carriers of the common glucocerebrosidase mutations, and among patients with Parkinson disease there is an increased number who are carriers of glucocerebrosidase mutations. A Gaucher mutation is considered a susceptibility factor for Parkinson's disease. Osteopontin single-nucleotide polymorphism–66 is associated with Lewy body disease and considered a susceptibility factor. The aim of this study was to ascertain whether Gaucher patients with parkinsonism carry the osteopontin single-nucleotide polymorphism-66 polymorphic genotype TT to a greater extent than other Gaucher patients.
Seventy adult patients with at least 1 allele having the common N370S Gaucher mutation including 10 patients with Parkinson's disease were included.
There was no statistically significant difference in incidence of the TT genotype in patients with clinically symptomatic Parkinson's disease (88.9%) and other Gaucher patients (72.1%).
This may partly explain the increased incidence of Parkinson's disease associated with Gaucher mutations. © 2011 Movement Disorder Society