Funding agencies: This study was funded by NIH grants KL2 RR024154, KMH082998, MH55762, UL1 RR024153, and P30 AG-024827, the Department of Veterans Affairs, and the American Parkinson Disease Association Center for Advanced Research at the University of Pittsburgh. Relevant conflicts of interest/financial disclosures: Nothing to report.
Pupillary unrest correlates with arousal symptoms and motor signs in Parkinson disease†
Article first published online: 19 APR 2011
Copyright © 2011 Movement Disorder Society
Volume 26, Issue 7, pages 1344–1347, June 2011
How to Cite
Jain, S., Siegle, G. J., Gu, C., Moore, C. G., Ivanco, L. S., Studenski, S., Greenamyre, J. T. and Steinhauer, S. R. (2011), Pupillary unrest correlates with arousal symptoms and motor signs in Parkinson disease. Mov. Disord., 26: 1344–1347. doi: 10.1002/mds.23628
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 20 JUN 2011
- Article first published online: 19 APR 2011
- Manuscript Accepted: 14 DEC 2010
- Manuscript Revised: 4 DEC 2010
- Manuscript Received: 19 JUL 2010
- nonmotor features;
- Parkinson's disease;
- sleep disorders;
- autonomic dysfunction
Arousal symptoms (e.g., sleepiness) are common in Parkinson's disease, and pupillary unrest (spontaneous changes in pupil diameter) is positively associated with sleepiness. We explored pupillary unrest in Parkinson's disease.
Arousal symptoms (Epworth sleepiness scale and sleep/fatigue domain of the nonmotor symptoms scale for Parkinson's disease) and pupillary unrest were assessed in 31 participants (14 patients with Parkinson's disease, 17 controls). Effect sizes and t tests compared patients with Parkinson's disease with control participants. Correlation coefficients were calculated among arousal symptoms, pupillary unrest, and Unified Parkinson Disease Rating Scale Part III. Linear regression was performed with arousal symptoms or pupillary unrest as outcome.
Participants with Parkinson's disease reported more arousal symptoms than controls. Pupillary unrest, arousal symptoms, and Unified Parkinson Disease Rating Scale Part III were positively correlated. The association between nonmotor symptoms scale–sleep score and pupillary unrest was higher in participants with Parkinson's disease than controls and higher in those with more Parkinsonian motor signs. Unified Parkinson Disease Rating Scale Part III was positively associated with pupillary unrest.
Pupillary unrest correlates with motor and nonmotor features associated with Lewy-related pathology, suggesting it may be a nonmotor marker of progression in Parkinson's disease. © 2011 Movement Disorder Society