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Keywords:

  • Parkinson's disease;
  • gastric myoelectrical activity;
  • motor fluctuations;
  • L-dopa plasmatic levels

Abstract

Background:

Gastroenteric dysfunctions are very common in Parkinson's disease, but their relationship with dopaminergic response and motor fluctuations is still unclear. Electrogastrography is a noninvasive method for measuring gastric myoelectrical activity.

Methods:

We evaluated the effects of levodopa intake on the motility of empty stomachs in Parkinson's disease patients with and without motor fluctuations.

Results:

The electrogastrography findings showed a normal pattern not influenced by levodopa intake, unrelated to plasmatic levodopa concentrations and to clinical parameters.

Conclusions:

Our results suggest that at rest gastric activity of Parkinson's disease patients is normal and plasmatic levodopa variability is not influenced by gastric motility. © 2011 Movement Disorder Society