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Electrogastrographyc activity in Parkinson's disease patients with and without motor fluctuations

Authors

  • Giovanni Albani MD,

    1. Division of Neurology and Neurorehabilitation, San Giuseppe Hospital, IRCCS–Istituto Auxologico Italiano, Piancavallo (VB), Italy
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  • Nadia El Assawy,

    1. Division of Neurology and Neurorehabilitation, San Giuseppe Hospital, IRCCS–Istituto Auxologico Italiano, Piancavallo (VB), Italy
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  • Stefania Cattaldo,

    1. Division of Neurology and Neurorehabilitation, San Giuseppe Hospital, IRCCS–Istituto Auxologico Italiano, Piancavallo (VB), Italy
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  • Marilena De Gennaro,

    1. Division of Neurology and Neurorehabilitation, San Giuseppe Hospital, IRCCS–Istituto Auxologico Italiano, Piancavallo (VB), Italy
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  • Francesca Gregorini,

    1. Division of Neurology and Neurorehabilitation, San Giuseppe Hospital, IRCCS–Istituto Auxologico Italiano, Piancavallo (VB), Italy
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  • Luca Pradotto MD,

    Corresponding author
    1. Division of Neurology and Neurorehabilitation, San Giuseppe Hospital, IRCCS–Istituto Auxologico Italiano, Piancavallo (VB), Italy
    • Divisione di Neurologia e Neuroriabilitazione, Ospedale San Giuseppe, IRCCS–Istituto Auxologico Italiano, Strada Cadorna n. 90, 28924 Oggebbio (VB), Italy
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  • Alessandro Mauro MD

    1. Division of Neurology and Neurorehabilitation, San Giuseppe Hospital, IRCCS–Istituto Auxologico Italiano, Piancavallo (VB), Italy
    2. Department of Neuroscience, University of Turin, Turin, Italy
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  • Relevant conflicts of interest/financial disclosures: Nothing to report.

    Full financial disclosures and author roles may be found in the online version of this article. This study was partially supported by the Italian Ministry of Health (project RFPS-2007-1-641398).

Abstract

Background:

Gastroenteric dysfunctions are very common in Parkinson's disease, but their relationship with dopaminergic response and motor fluctuations is still unclear. Electrogastrography is a noninvasive method for measuring gastric myoelectrical activity.

Methods:

We evaluated the effects of levodopa intake on the motility of empty stomachs in Parkinson's disease patients with and without motor fluctuations.

Results:

The electrogastrography findings showed a normal pattern not influenced by levodopa intake, unrelated to plasmatic levodopa concentrations and to clinical parameters.

Conclusions:

Our results suggest that at rest gastric activity of Parkinson's disease patients is normal and plasmatic levodopa variability is not influenced by gastric motility. © 2011 Movement Disorder Society

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