Relevant conflicts of interest/financial disclosures: Nothing to report.
Parkinson's disease: The quintessential neuropsychiatric disorder†
Article first published online: 27 MAY 2011
Copyright © 2011 Movement Disorder Society
Special Issue: 25th Anniversary
Volume 26, Issue 6, pages 1022–1031, May 2011
How to Cite
Weintraub, D. and Burn, D. J. (2011), Parkinson's disease: The quintessential neuropsychiatric disorder. Mov. Disord., 26: 1022–1031. doi: 10.1002/mds.23664
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 26 MAY 2011
- Article first published online: 27 MAY 2011
- Manuscript Accepted: 6 JAN 2011
- Manuscript Revised: 26 DEC 2010
- Manuscript Received: 22 SEP 2010
Although diagnosed by characteristic motor features, Parkinson's disease may be preceded, and is frequently accompanied by, a wide range of cognitive and neuropsychiatric features. In addition to the most commonly studied disorders of dementia, depression, and psychosis, other relatively common and clinically significant psychiatric complications include impulse control disorders, anxiety symptoms, disorders of sleep and wakefulness, and apathy. These problems may be underrecognized and are frequently undertreated. The emergent focus on nonmotor aspects of Parkinson's disease over the past quarter of a century is highlighted by a nonlinear increase in the number of articles published devoted to this topic. Although the development of newer antidepressants, atypical antipsychotics, and cholinesterase inhibitors in recent years has had a positive benefit on the management of these troublesome and distressing symptoms, responses are frequently suboptimal, and this remains an area of major unmet therapeutic need. © 2011 Movement Disorder Society