Relevant conflicts of interest/financial disclosures: Nothing to report.
Late-onset asymmetric myoclonus: An emerging syndrome†
Version of Record online: 26 MAY 2011
Copyright © 2011 Movement Disorder Society
Volume 26, Issue 9, pages 1744–1747, 1 August 2011
How to Cite
Katschnig, P., Massano, J., Edwards, M. J., Schwingenschuh, P., Cordivari, C. and Bhatia, K. P. (2011), Late-onset asymmetric myoclonus: An emerging syndrome. Mov. Disord., 26: 1744–1747. doi: 10.1002/mds.23676
This research was supported by National Institutes of Health Grants R01 NS39422, P30 ES09089, P42 ES10349, and R01 CA102484.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue online: 9 AUG 2011
- Version of Record online: 26 MAY 2011
- Manuscript Accepted: 13 JAN 2011
- Manuscript Revised: 31 DEC 2010
- Manuscript Received: 20 MAR 2010
Asymmetric cortical myoclonus is typically thought to be associated with either contralateral cortical structural lesions or degenerative disorders such as corticobasal degeneration when onset is in middle-aged or aged adults. This view has been challenged after a recent case series brought to light a syndrome of senile-onset, asymmetric cortical myoclonus not associated with any such identifiable disorders, thus, named “primary progressive myoclonus of aging.” This is rare and no other reports have been published; hence, further such cases need to be highlighted.
Here, we describe 3 patients with some similarities, namely, adult-onset, asymmetric myoclonus that is most likely to be cortical, with an unremarkable thorough diagnostic workup, but with younger age at onset and longer follow-up time.
This report expands on previous phenotypical descriptions attempting to further develop and refine this possible diagnostic entity. © 2011 Movement Disorder Society