Relevant conflicts of interest/financial disclosures: Nothing to report.
Article first published online: 29 APR 2011
Copyright © 2011 Movement Disorder Society
Volume 26, Issue 8, pages 1529–1533, July 2011
How to Cite
Postuma, R. B., Montplaisir, J., Lanfranchi, P., Blais, H., Rompré, S., Colombo, R. and Gagnon, J.-F. (2011), Cardiac autonomic denervation in Parkinson's disease is linked to REM sleep behavior disorder. Mov. Disord., 26: 1529–1533. doi: 10.1002/mds.23677
This study was supported by the Canadian Institutes of Health Research and by the Fonds de la recherche en santé du Québec.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 21 JUL 2011
- Article first published online: 29 APR 2011
- Manuscript Accepted: 20 JAN 2011
- Manuscript Revised: 29 DEC 2010
- Manuscript Received: 11 NOV 2010
- rapid eye movement sleep behavior disorder;
- Parkinson's disease;
Recent studies have suggested a close connection between autonomic dysfunction and rapid eye movement sleep behavior disorder, which differs in nature from other early-stage markers of Parkinson's disease. In this study we examined the relationship between rapid eye movement sleep behavior disorder and autonomic dysfunction in Parkinson's disease as measured by cardiac beat-to-beat variability.
In 53 patients with Parkinson's disease and 36 controls, electrocardiographic trace from a polysomnogram was assessed for measures of beat-to-beat RR variability including RR-standard deviation and frequency domains (low- and high-frequency components). Results were compared between patients with Parkinson's disease and controls, and between patients with Parkinson's disease with and without rapid eye movement sleep behavior disorder.
On numerous cardiac autonomic measures, patients with Parkinson's disease showed clear abnormalities compared with controls. However, these abnormalities were confined only to those patients with associated rapid eye movement sleep behavior; those without were not different than controls.
As with other clinical autonomic variables, cardiac autonomic denervation is predominantly associated not with Parkinson's disease itself, but with the presence of rapid eye movement sleep behavior disorder. © 2011 Movement Disorder Society