Relevant conflicts of interest/financial disclosures: Maja Kojovic has received honoraria for conference travel from EFNS, Movement Disorders Society, Guarantors of Brain, Ipsen, and UCB; Grants from EFNS Scientific Fellowship Grant 2009 and a Lady Astor PhD Grant; and is employed by the Department of Neurology, University of Ljubljana, Slovenia. Antonio Caronni is employed by the Department of Human Physiology, University of Milan, Italy. Matteo Bologna has received an ENS Fellowship Grant 2009 and is employed by the “Sapienza” University of Rome, Italy. John C. Rothwell has received honoraria for conference travel and meetings from the Movement Disorders Society, grants from the Dystonia Medical Research Foundation, Tourette Syndrome Association, and the FP7 Collaborative Project (222918 and 223524), and is employed by University College London. Kailash P. Bhatia is a member of the Movement Disorders Society Scientific Advisory Board, has received honoraria from GSK, Boehringer-Ingelheim, Ipsen, Merz, and Orion pharmaceutical companies and grants from the Wellcome Trust and an MRC award (ref. WT089698), and a Halley Stewart Trust grant through the Dystonia Society UK, and is employed by University College London. Mark J. Edwards has received honoraria from Teva Pharmaceuticals and Orio, an NIHR Clinician Scientist Grant, is employed by University College London, and has received royalties from Oxford University Press for Oxford Specialist Handbook of Parkinson's Disease and Other Movement Disorders.
Article first published online: 5 APR 2011
Copyright © 2011 Movement Disorder Society
Volume 26, Issue 7, pages 1282–1289, June 2011
How to Cite
Kojovic, M., Caronni, A., Bologna, M., Rothwell, J. C., Bhatia, K. P. and Edwards, M. J. (2011), Botulinum toxin injections reduce associative plasticity in patients with primary dystonia. Mov. Disord., 26: 1282–1289. doi: 10.1002/mds.23681
This work was undertaken at UCLH/UCL, which received a proportion of funding from the Department of Health's NIHR Biomedical Research Centres funding scheme.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 20 JUN 2011
- Article first published online: 5 APR 2011
- Manuscript Accepted: 24 JAN 2011
- Manuscript Revised: 27 DEC 2010
- Manuscript Received: 23 NOV 2010
Additional Supporting Information may be found in the online version of this article.
|MDS_23681_sm_suppfig1.tif||2807K||Supporting Figure 1 IO curves before and after BT injections. The mean MEP amplitude (±SEM) is given on the y-axis against the stimulus intensity given on the x-axis (in percentage of 1mV stimulus intensity). The IO curves measured before BT injections, 1 month after and 3 months after BT injections were not significantly different.|
|MDS_23681_sm_suppfig2.tif||67K||Supporting Figure 2 Effect of paired associative stimulation (rPAS) on motor evoked potential (MEP) amplitude before BT injections, 1 month and 3 months after BT injections. The graph shows the mean amplitude of the MEPs collected 0, 30 and 60 min after rPAS, expressed as a percentage of the baseline MEP size (before rPAS). rPAS produced similar amount of facilitation in APB and FDI muscle before BT injections. 1 month after BT injections response to rPAS was abolished in both muscles, while 3 months after BT it partially recovered in both APB and FDI. * p< 0.05.|
|MDS_23681_sm_suppfig3.tif||62K||Supporting Figure 3 SICI and ICF, in response to rPAS and BT injections. SICI at an ISI of 2ms and ICF at an ISI of 12 ms are unchanged in response to rPAS and after BT injections.|
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