Anna Prats París and Heidi Guerra Saleta contributed equally to this work.
Blind randomized controlled study of the efficacy of cognitive training in Parkinson's disease†
Article first published online: 25 MAR 2011
Copyright © 2011 Movement Disorder Society
Volume 26, Issue 7, pages 1251–1258, June 2011
How to Cite
París, A. P., Saleta, H. G., de la Cruz Crespo Maraver, M., Silvestre, E., Freixa, M. G., Torrellas, C. P., Pont, S. A., Nadal, M. F., Garcia, S. A., Bartolomé, M. V. P., Fernández, V. L. and Bayés, À. R. (2011), Blind randomized controlled study of the efficacy of cognitive training in Parkinson's disease. Mov. Disord., 26: 1251–1258. doi: 10.1002/mds.23688
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 20 JUN 2011
- Article first published online: 25 MAR 2011
- Manuscript Accepted: 28 JAN 2011
- Manuscript Revised: 25 JAN 2011
- Manuscript Received: 22 JUN 2010
- Parkinson's disease;
- cognitive training neuropsychology;
- cognitive impairment
The aim of this study was to analyze the efficacy of a cognitive training program on cognitive performance and quality of life in nondemented Parkinson's disease patients. Participants who met UK Brain Bank diagnosis criteria for Parkinson's disease, with I–III Hoehn & Yahr, aged 50–80, and nondemented (Mini-Mental State Examination ≥ 23) were recruited. Patient's cognitive performance and functional and quality-of-life measures were assessed with standardized neuropsychological tests and scales at baseline and after 4 weeks. Subjects were randomly and blindly allocated by age and premorbid intelligence (Vocabulary, Wechsler Adult Intelligence Scale-III) into 2 groups: an experimental group and a control group. The experimental group received 4 weeks of 3 weekly 45-minute sessions using multimedia software and paper-and-pencil cognitive exercises, and the control group received speech therapy. A total of 28 patients were analyzed. Compared with the control group participants (n = 12), the experimental group participants (n = 16) demonstrated improved performance in tests of attention, information processing speed, memory, visuospatial and visuoconstructive abilities, semantic verbal fluency, and executive functions. There were no observable benefits in self-reported quality of life or cognitive difficulties in activities of daily living. We concluded that intensive cognitive training may be a useful tool in the management of cognitive functions in Parkinson's disease. © 2011 Movement Disorder Society