Yi Guo and Wei-Dong Le contributed equally to this article.
Article first published online: 5 APR 2011
Copyright © 2011 Movement Disorder Society
Volume 26, Issue 9, pages 1729–1732, 1 August 2011
How to Cite
Guo, Y., Le, W.-D., Jankovic, J., Yang, H.-R., Xu, H.-B., Xie, W.-J., Song, Z. and Deng, H. (2011), Systematic genetic analysis of the PITX3 gene in patients with Parkinson disease. Mov. Disord., 26: 1729–1732. doi: 10.1002/mds.23693
Relevant conflicts of interest/financial disclosures: Nothing to report.
This work was supported by Central South University, Changsha, China, and Baylor College of Medicine, Houston, Texas.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 9 AUG 2011
- Article first published online: 5 APR 2011
- Manuscript Accepted: 1 FEB 2011
- Manuscript Revised: 17 JAN 2011
- Manuscript Received: 20 JUN 2010
- Parkinson disease;
- transcription factor;
- paired-like homodomain transcription factor 3;
Paired-like homodomain transcription factor 3 has been found to be important for the differentiation and survival of midbrain dopaminergic neurons.
To determine whether genetic variation in the coding region of the paired-like homodomain transcription factor 3 gene plays a role in Parkinson's disease, genetic analysis was performed in 112 patients with Parkinson's disease.
We did not identify any mutations except rs2281983, but when we extended the analysis of rs2281983 and 2 intron variants (rs4919621 and rs3758549) in 336 patients with Parkinson's disease and 244 controls, we found that rs2281983 and rs4919621 appeared to confer susceptibility to Parkinson's disease, especially in early-onset Parkinson's disease and familial Parkinson's disease. © 2011 Movement Disorder Society