Relevant conflicts of interest/financial disclosures: Nothing to report.
Article first published online: 21 MAR 2011
Copyright © 2011 Movement Disorder Society
Volume 26, Issue 5, pages 870–876, April 2011
How to Cite
Schmitz-Hübsch, T., Coudert, M., Tezenas du Montcel, S., Giunti, P., Labrum, R., Dürr, A., Ribai, P., Charles, P., Linnemann, C., Schöls, L., Rakowicz, M., Rola, R., Zdzienicka, E., Fancellu, R., Mariotti, C., Baliko, L., Melegh, B., Filla, A., Salvatore, E., van de Warrenburg, B. P.C., Szymanski, S., Infante, J., Timmann, D., Boesch, S., Depondt, C., Kang, J.-S., Schulz, J. B., Klopstock, T., Lossnitzer, N., Löwe, B., Frick, C., Rottländer, D., Schlaepfer, T. E. and Klockgether, T. (2011), Depression comorbidity in spinocerebellar ataxia. Mov. Disord., 26: 870–876. doi: 10.1002/mds.23698
The study was supported by grant EUROSCA/LSHM-CT-2004-503304 from the European Union (to T. Schmitz-Hübsch, S. Tezenas du Montcel, P. Giunti, L. Schöls, M. Rakowicz, R. Rola, E. Zdzienicka, R. Fancellu, C. Mariotti, B. Melegh, A. Filla, B.P.C. van de Warrenburg, J. Infante, S. Boesch, C. Depondt, J.-S. Kang, J. Schulz, T. Klockgether), grant GeneMove/01 GM 0503 from the German Ministry of Education and Research (to D. Timmann, L. Schöls, J.-S. Kang, J. Schulz, T. Klopstock, T. Klockgether), and grant 3 PO5B 019 24 from the Polish Ministry of Scientific Research and Information Technology (to R. Rola).
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 21 APR 2011
- Article first published online: 21 MAR 2011
- Manuscript Accepted: 7 FEB 2011
- Manuscript Revised: 3 FEB 2011
- Manuscript Received: 16 JUL 2010
- spinocerebellar ataxia;
- prevalence studies
This is a description of the prevalence and profile of depressive symptoms in dominant spinocerebellar ataxia (SCA). Depressive symptoms were assessed in a convenience sample of 526 genetically confirmed and clinically affected patients (117 SCA1, 163 SCA2, 139 SCA3, and 107 SCA6) using the Patient Health Questionnaire (PHQ). In addition, depressive status according to the examiner and the use of antidepressants was recorded. Depression self-assessment was compared with an interview-based psychiatric assessment in a subset of 26 patients. Depression prevalence estimates were 17.1% according to the PHQ algorithm and 15.4% when assessed clinically. The sensitivity of clinical impression compared with PHQ classification was low (0.35), whereas diagnostic accuracy of PHQ compared with psychiatric interview in the subset was high. Antidepressants were used by 17.7% of patients and in >10% of patients without current clinically relevant depressive symptoms. Depression profile in SCA did not differ from a sample of patients with major depressive disorder except for the movement-related item. Neither depression prevalence nor use of antidepressants differed between genetic subtypes, with only sleep disturbance more common in SCA3. In a multivariate analysis, ataxia severity and female sex independently predicted depressive status in SCA. The PHQ algorithmic classification is appropriate for use in SCA but should stimulate further psychiatric evaluation if depression is indicated. Despite a higher risk for depression with more severe disease, the relation of depressive symptoms to SCA neurodegeneration remains to be shown. © 2011 Movement Disorder Society