Funding agencies: This study was supported by grants from the Fonds de la Recherche en Santé du Québec and the Canadian Institutes of Health Research to Jean-François Gagnon, Jean-Paul Soucy, Ronald B. Postuma, and Jacques Montplaisir.
Article first published online: 3 MAY 2011
Copyright © 2011 Movement Disorder Society
Volume 26, Issue 9, pages 1717–1724, 1 August 2011
How to Cite
Vendette, M., Gagnon, J.-F., Soucy, J.-P., Gosselin, N., Postuma, R. B., Tuineag, M., Godin, I. and Montplaisir, J. (2011), Brain perfusion and markers of neurodegeneration in rapid eye movement sleep behavior disorder. Mov. Disord., 26: 1717–1724. doi: 10.1002/mds.23721
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 9 AUG 2011
- Article first published online: 3 MAY 2011
- Manuscript Accepted: 24 FEB 2011
- Manuscript Revised: 4 FEB 2011
- Manuscript Received: 23 SEP 2010
- rapid eye movement sleep behavior disorder;
- single-photon emission computerized tomography (regional cerebral blood flow);
- Parkinson's disease;
- Lewy body dementia;
- markers of neurodegeneration
Potential early markers of neurodegeneration such as subtle motor signs, reduced color discrimination, olfactory impairment, and brain perfusion abnormalities have been reported in idiopathic rapid eye movement sleep behavior disorder, a risk factor for Parkinson's disease and Lewy body dementia. The aim of this study was to reproduce observations of regional cerebral blood flow abnormalities in a larger independent sample of patients and to explore correlations between regional cerebral blood flow and markers of neurodegeneration. Twenty patients with idiopathic rapid eye movement sleep behavior disorder and 20 healthy controls were studied by single-photon emission computerized tomography. Motor examination, color discrimination, and olfactory identification were examined. Patients with rapid eye movement sleep behavior disorder showed decreased regional cerebral blood flow in the frontal cortex and in medial parietal areas and increased regional cerebral blood flow in subcortical regions including the bilateral pons, putamen, and hippocampus. In rapid eye movement sleep behavior disorder, brain perfusion in the frontal cortex and occipital areas was associated with poorer performance in the color discrimination test. Moreover, a relationship between loss of olfactory discrimination and regional cerebral blood flow reduction in the bilateral anterior parahippocampal gyrus, a region known to be involved in olfactory functions, was found. This study provides further evidence of regional cerebral blood flow abnormalities in rapid eye movement sleep behavior disorder that are similar to those seen in Parkinson's disease and Lewy body dementia. Moreover, regional cerebral blood flow anomalies were associated with markers of neurodegeneration. © 2011 Movement Disorder Society