Brain perfusion and markers of neurodegeneration in rapid eye movement sleep behavior disorder§

Authors

  • Mélanie Vendette MSc,

    1. Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, Montreal, Quebec, Canada
    2. Department of Psychology, University of Montreal, Montreal, Quebec, Canada
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  • Jean-François Gagnon PhD,

    1. Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, Montreal, Quebec, Canada
    2. Department of Psychology, Université du Québec à Montréal, Montreal, Quebec, Canada
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  • Jean-Paul Soucy MD, MSc,

    1. Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    2. Department of Nuclear Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada
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  • Nadia Gosselin PhD,

    1. Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, Montreal, Quebec, Canada
    2. Department of Psychiatry, University of Montreal, Montreal, Quebec, Canada
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  • Ronald B. Postuma MD, MSc,

    1. Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, Montreal, Quebec, Canada
    2. Department of Neurology, Montreal General Hospital, Montreal, Quebec, Canada
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  • Maria Tuineag MD,

    1. Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, Montreal, Quebec, Canada
    2. Department of Psychiatry, University of Montreal, Montreal, Quebec, Canada
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  • Isabelle Godin BSc,

    1. Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, Montreal, Quebec, Canada
    2. Department of Psychology, University of Montreal, Montreal, Quebec, Canada
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  • Jacques Montplaisir MD, PhD, CRCPc

    Corresponding author
    1. Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, Montreal, Quebec, Canada
    2. Department of Psychiatry, University of Montreal, Montreal, Quebec, Canada
    • Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, 5400 boul. Gouin Ouest, Montréal, Québec, Canada H4J 1C5
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  • Funding agencies: This study was supported by grants from the Fonds de la Recherche en Santé du Québec and the Canadian Institutes of Health Research to Jean-François Gagnon, Jean-Paul Soucy, Ronald B. Postuma, and Jacques Montplaisir.

  • Relevant conflicts of interest/financial disclosures: Nothing to report.

  • §

    Full financial disclosures and author roles may be found in the online version of this article.

Abstract

Potential early markers of neurodegeneration such as subtle motor signs, reduced color discrimination, olfactory impairment, and brain perfusion abnormalities have been reported in idiopathic rapid eye movement sleep behavior disorder, a risk factor for Parkinson's disease and Lewy body dementia. The aim of this study was to reproduce observations of regional cerebral blood flow abnormalities in a larger independent sample of patients and to explore correlations between regional cerebral blood flow and markers of neurodegeneration. Twenty patients with idiopathic rapid eye movement sleep behavior disorder and 20 healthy controls were studied by single-photon emission computerized tomography. Motor examination, color discrimination, and olfactory identification were examined. Patients with rapid eye movement sleep behavior disorder showed decreased regional cerebral blood flow in the frontal cortex and in medial parietal areas and increased regional cerebral blood flow in subcortical regions including the bilateral pons, putamen, and hippocampus. In rapid eye movement sleep behavior disorder, brain perfusion in the frontal cortex and occipital areas was associated with poorer performance in the color discrimination test. Moreover, a relationship between loss of olfactory discrimination and regional cerebral blood flow reduction in the bilateral anterior parahippocampal gyrus, a region known to be involved in olfactory functions, was found. This study provides further evidence of regional cerebral blood flow abnormalities in rapid eye movement sleep behavior disorder that are similar to those seen in Parkinson's disease and Lewy body dementia. Moreover, regional cerebral blood flow anomalies were associated with markers of neurodegeneration. © 2011 Movement Disorder Society

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