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Diffusion tensor magnetic resonance imaging tractography in progressive supranuclear palsy

Authors

  • Elisa Canu MSc,

    1. Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy
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  • Federica Agosta MD,

    1. Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy
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  • Francesca Baglio MD,

    1. Department of Neurology, Scientific Institute Fondazione Don Gnocchi, Milan, Italy
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  • Sebastiano Galantucci MD,

    1. Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy
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  • Raffaello Nemni MD,

    1. Department of Neurology, Scientific Institute Fondazione Don Gnocchi, Milan, Italy
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  • Massimo Filippi MD

    Corresponding author
    1. Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy
    • Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Via Olgettina, 60, 20132 Milan, Italy
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  • Relevant conflicts of interest/financial disclosures: Nothing to report.

  • Full financial disclosures and author roles may be found in the online version of this article.

Abstract

Background:

Diffusion tensor magnetic resonance imaging tractography allows quantification of in vivo white matter tract damage.

Methods:

Using tractography, diffusion tensor magnetic resonance imaging metrics were obtained from the superior and middle cerebellar peduncles and major cerebral white matter tracts in 5 patients with progressive supranuclear palsy and 13 controls.

Results:

Patients showed severe intrinsic damage to the superior cerebellar peduncle, corpus callosum, and cingulum bilaterally. Only decreased axial diffusivity was found in the left middle cerebellar peduncle.

Conclusions:

Diffusion tensor magnetic resonance imaging tractography holds promise for providing accurate in vivo cartography of progressive supranuclear palsy tissue damage. © 2011 Movement Disorder Society

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