Funding agencies: This project was supported by the Parkinson's Study Group, the National Parkinson's Foundation and the Michael J. Fox Foundation.
Article first published online: 24 MAY 2011
Copyright © 2011 Movement Disorder Society
Volume 26, Issue 10, pages 1875–1880, 15 August 2011
How to Cite
Shanker, V., Groves, M., Heiman, G., Palmese, C., Saunders-Pullman, R., Ozelius, L., Raymond, D. and Bressman, S. (2011), Mood and cognition in leucine-rich repeat kinase 2 G2019S Parkinson's disease. Mov. Disord., 26: 1875–1880. doi: 10.1002/mds.23746
Relevant conflicts of interest/financial disclosures: Nothing to report. Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 26 AUG 2011
- Article first published online: 24 MAY 2011
- Manuscript Accepted: 15 MAR 2011
- Manuscript Revised: 5 MAR 2011
- Manuscript Received: 21 DEC 2010
Vol. 26, Issue 14, 2586, Article first published online: 14 DEC 2011
- Parkinson's disease;
- leucine-rich repeat kinase 2;
The behavioral and cognitive features of the leucine-rich repeat kinase G2019S mutation in Parkinson's disease in the Ashkenazi Jewish population are not well described; therefore, we sought to more systematically characterize these features using a semistructured psychiatric interview and neuropsychological testing. Twenty-one Ashkenazi Jewish patients having the leucine-rich repeat kinase G2019S mutation were compared with age- and sex-matched Ashkenazi Jewish patients with Parkinson's disease without mutations. Although overall rates of affective disorders were not greater in mutation carriers, the carriers exhibited a 6-fold increased risk of premorbid affective disorders (odds ratio, 6.0; P = .10), as determined by the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders–IV. Of interest, we identified 2 leucine-rich repeat kinase carriers with bipolar disorder; no mutation-negative subjects had this diagnosis. Performance on the Hopkins Verbal Learning Test–Revised, Judgment of Line Orientation, and Frontal Assessment Battery was consistent with previous reports and did not differ between groups. Study findings suggest a possible association between premorbid mood disorders and leucine-rich repeat kinase Parkinson's disease, warranting further evaluation. © 2011 Movement Disorder Society