Funding agencies: This work was funded by the Parkinson's UK (Grant 8034), Ipsen Fund.
Article first published online: 13 MAY 2011
Copyright © 2011 Movement Disorder Society
Volume 26, Issue 11, pages 2011–2018, September 2011
How to Cite
Knipe, M. D. W., Wickremaratchi, M. M., Wyatt-Haines, E., Morris, H. R. and Ben-Shlomo, Y. (2011), Quality of life in young- compared with late-onset Parkinson's disease. Mov. Disord., 26: 2011–2018. doi: 10.1002/mds.23763
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 19 SEP 2011
- Article first published online: 13 MAY 2011
- Manuscript Accepted: 28 MAR 2011
- Manuscript Revised: 14 MAR 2011
- Manuscript Received: 18 AUG 2010
- quality of life;
- Parkinson's disease;
- age of onset;
- excessive somnolence disorder
The impact of Parkinson's disease on quality of life may vary depending on age at onset. We investigated the effect of age at onset on quality of life in a large Parkinson's disease population (n = 426) using a disease-specific rating scale (PDQ-39) and with careful adjustment for confounding and intermediary factors. We also explored the relationship between depression and excessive daytime sleepiness by age at onset and compared this with the general population. We found that a younger age at onset was significantly associated with worse overall quality of life scores (odds ratio, 2.66; 95% confidence interval, 1.39–5.09; P = .003), but this was attenuated by adjustment for depression as an intermediary factor (odds ratio, 1.86; 95% confidence interval, 0.84–4.11; P = .13). Younger onset was also a risk factor for poor emotional well-being independent of depression status. Risk of depression and excessive daytime sleepiness were elevated in patients with Parkinson's disease compared with controls (odds ratio, 2.99; 95% confidence interval, 1.93–4.65; P < .001; and odds ratio, 3.84; 95% confidence interval, 2.56–5.75; P < .001, respectively), with similar findings seen in both early- and late-onset groups. Our study highlights the need for accurate diagnosis and treatment of depression in younger-onset patients in order to improve quality of life. © 2011 Movement Disorder Society