Funding agencies: Work in the Futerman laboratory on Gaucher disease is supported by the Children's Gaucher Research Fund and Merck KGaA.
Article first published online: 26 MAY 2011
Copyright © 2011 Movement Disorder Society
Volume 26, Issue 9, pages 1593–1604, 1 August 2011
How to Cite
Shachar, T., Bianco, C. L., Recchia, A., Wiessner, C., Raas-Rothschild, A. and Futerman, A. H. (2011), Lysosomal storage disorders and Parkinson's disease: Gaucher disease and beyond. Mov. Disord., 26: 1593–1604. doi: 10.1002/mds.23774
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 9 AUG 2011
- Article first published online: 26 MAY 2011
- Manuscript Accepted: 6 APR 2011
- Manuscript Revised: 28 MAR 2011
- Manuscript Received: 16 JAN 2011
- Gaucher disease;
- Parkinson's disease;
- lysosomal storage disorders;
- neurodegenerative diseases
Parkinson's disease is associated with mutations in the glucocerebrosidase gene, which result in the enzyme deficiency causing Gaucher disease, the most common lysosomal storage disorder. We have performed an exhaustive literature search and found that additional lysosomal storage disorders might be associated with Parkinson's disease, based on case reports, the appearance of pathological features such as α-synuclein deposits in the brain, and substantia nigra pathology. Our findings suggest that the search for biochemical and cellular pathways that link Parkinson's disease with lysosomal storage disorders should not be limited exclusively to changes that occur in Gaucher disease, such as changes in glucocerebrosidase activity or in glucosylceramide levels, but rather include changes that might be common to a wide variety of lysosomal storage disorders. Moreover, we propose that additional genetic, epidemiological, and clinical studies should be performed to check the precise incidence of mutations in genes encoding lysosomal proteins in patients displaying Parkinson's symptoms. © 2011 Movement Disorder Society