Funding agencies: This study was supported by the Higher Education Commission (HEC), Pakistan, the German Research Foundation (DFG), Germany, the Volkswagen Foundation, and the Hermann and Lilly Schilling Foundation (Germany).
Version of Record online: 23 SEP 2011
Copyright © 2011 Movement Disorder Society
Volume 26, Issue 12, pages 2279–2283, October 2011
How to Cite
Arif, B., Grünewald, A., Fatima, A., Ramirez, A., Ali, A., Brüggemann, N., Würfel, J., Rolfs, A., Lohmann, K., Malik, A., Klein, C. and Naz, S. (2011), An unusual neurological syndrome of crawling gait, dystonia, pyramidal signs, and limited speech. Mov. Disord., 26: 2279–2283. doi: 10.1002/mds.23860
Relevant conflicts of interest/financial disclosures: Nothing to report.
- Issue online: 21 OCT 2011
- Version of Record online: 23 SEP 2011
- Manuscript Accepted: 8 JUN 2011
- Manuscript Revised: 3 MAY 2011
- Manuscript Received: 9 MAR 2011
Additional Supporting Information may be found in the online version of this article.
|MDS_23860_sm_SuppTab1.doc||30K||Table e-1: Linkage Intervals for family DYAF07.|
|MDS_23860_sm_SuppTab2.doc||28K||Table e-2 Exclusion mapping of CA8 in family DYAF07.|
|MDS_23860_sm_SuppFig1.tif||6757K||Figure e-1. Haplotypes of family DYAF07 as generated by Haplopainter after analysis of SNP data with markers at the CA8 chromosomal interval. The five affected individuals have different haplotypes and the same haplotype combinations are present in unaffected siblings VI:4 and VI:5 also. For clarity, haplotypes of all affected individuals are shown next to one another, regardless of their position in the pedigree. The location of SNP markers are shown according to the deCODE genetic map.|
|MDS_23860_sm_SuppMov1.mpg||2358K||Supporting Video 1 (VI:7). The patient ambulates on hands and knees by hopping and crossing his legs at the back. He propels his trunk with a hop while his legs are held in a dystonic posture.|
|MDS_23860_sm_SuppMov2.mpg||4977K||Supporting Video 2 (VI:6). The first segment shows a “spontaneous” Babinski sign more pronounced on the left. Ambulation is similar to that of her brother (VI:7). With assistance, the patient displays a severely dystonic-spastic gait.|
|MDS_23860_sm_SuppMov3.mpg||4258K||Supporting Video 3 (VI:3). The first segment shows leg spasticity and Oppenheim's reflex of the left leg. The patient and her brother (VI:2) are able to walk without assistance, but present with a dystonic-spastic, hyperlordotic gait.|
|MDS_23860_sm_SuppMov4.mpg||4521K||Supporting Video 4 (VI:1). The patient has a severely dystonic gait; walking is only possible with assistance. He shows a dystonic smile when sitting.|
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