Funding agencies: The ANIMO was supported by an educational grant from Boehringer Ingelheim Spain.
Article first published online: 20 JUL 2011
Copyright © 2011 Movement Disorder Society
Volume 27, Issue 2, pages 211–218, February 2012
How to Cite
Benito-León, J., Cubo, E., Coronell, C. and on behalf of the ANIMO Study Group (2012), Impact of apathy on health-related quality of life in recently diagnosed Parkinson's disease: The ANIMO study. Mov. Disord., 27: 211–218. doi: 10.1002/mds.23872
Relevant conflicts of interest/financial disclosures: Julián Benito-León is supported by NIH R01 NS039422 from the National Institutes of Health (Bethesda, MD).
Full financial disclosures and author roles may be found in the online version of this article.
This article first published online 20 July 2011. The article has since changed. The phrase “than did participants who did not report any problems” was changed to “than participants who scored ≥0.89.”
- Issue published online: 9 FEB 2012
- Article first published online: 20 JUL 2011
- Manuscript Accepted: 15 JUN 2011
- Manuscript Revised: 24 MAY 2011
- Manuscript Received: 31 MAR 2011
- Parkinson's disease;
- quality of life;
The impact of apathy on health-related quality of life (HRQOL) in recently diagnosed Parkinson's disease (PD) has not been systematically investigated. The objective of this cross-sectional survey (ANIMO study) was to examine the contribution of apathy to HRQOL in a Spanish sample of recently diagnosed PD patients. PD patients, diagnosed within 2 years of inclusion, were recruited at 102 outpatient clinics in 82 communities throughout Spain. Apathy was quantified using the Lille Apathy Rating Scale and HRQOL with the EuroQol-5D questionnaire. A mean EuroQol-5D index score of 0.89 obtained from population references in Spain was used as the cutoff for this study. The relationship between apathy and the dichotomized EuroQol-5D index score (<0.89 [lower HRQOL] vs ≥0.89 [reference]) was examined using multiple logistic regression analysis, adjusting for sociodemographic and clinical variables. We consecutively recruited 557 patients (60.3% men) with a mean age of 68.8 ± 9.7 years. Apathy was diagnosed in 291 (52.2%) and was related to problems in each of the EuroQoL dimensions. Apathetic PD patients showed EuroQol-5D index scores significantly lower than those without apathy (0.64 vs 0.83). In an adjusted model, apathetic PD patients were 2.49 times more likely to have lower HRQOL than nonapathetic patients (odds ratio, 2.49; 95% confidence interval, 1.49–4.15, P < 0.01). Apathy is very common in those with recently diagnosed PD and is one of the major clinical determinants of HRQOL in this disease. It should be one of the primary concerns among clinicians who provide treatment to individuals affected by PD. © 2011 Movement Disorder Society