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Regional alterations of brain microstructure in Parkinson's disease using diffusion tensor imaging§

Authors

  • Wang Zhan PhD,

    Corresponding author
    1. Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, California, USA
    • Department of Radiology, University of California, San Francisco, VA Medical Center 114M, 4150 Clement Street, San Francisco, CA 94121, USA
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  • Gail A. Kang MD,

    1. Parkinson's Disease Research, Education, and Clinical Center, San Francisco VA Medical Center, San Francisco, California, USA
    2. Department of Neurology, University of California, San Francisco, California, USA
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  • Graham A. Glass,

    1. Parkinson's Disease Research, Education, and Clinical Center, San Francisco VA Medical Center, San Francisco, California, USA
    2. Department of Neurology, University of California, San Francisco, California, USA
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  • Yu Zhang MD,

    1. Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, California, USA
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  • Cheryl Shirley MS,

    1. Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, California, USA
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  • Rachel Millin PhD,

    1. Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, California, USA
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  • Katherine L. Possin PhD,

    1. Department of Neurology, University of California, San Francisco, California, USA
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  • Marzieh Nezamzadeh PhD,

    1. Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, California, USA
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  • Michael W. Weiner MD,

    1. Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, California, USA
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  • William J. Marks Jr. MD,

    1. Parkinson's Disease Research, Education, and Clinical Center, San Francisco VA Medical Center, San Francisco, California, USA
    2. Department of Neurology, University of California, San Francisco, California, USA
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  • Norbert Schuff PhD

    1. Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, California, USA
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  • Funding agencies: This work was supported in part by the Michael J. Fox Foundation for Parkinson's Research, “Multimodal MRI Markers for Parkinson's Disease” (MJJF-BM2007); NIH/NIRR “Research Resource for MRI of Neurodegenerative Disorders” (1 P41RR023953); and the Larry L. Hillblom Foundation, “Early markers and brain bases of spatial impairment in alpha-synuclein disorders” (2008-A-020-FEL).

  • Relevant conflicts of interest/financial disclosures: Nothing to report.

  • §

    Full financial disclosures and author roles may be found in the online version of this article.

Abstract

This study tested the hypothesis that diffusion tensor imaging can detect alteration in microscopic integrity of white matter and basal ganglia regions known to be involved in Parkinson's disease (PD) pathology. It was also hypothesized that there is an association between diffusion abnormality and PD severity and subtype. Diffusion tensor imaging at 4 Tesla was obtained in 12 PD and 20 control subjects, and measures of fractional anisotropy and mean diffusivity were evaluated using both region-of-interest and voxel-based methods. Movement deficits and subtypes in PD subjects were assessed using the Motor Subscale (Part III) of the Unified Parkinson's Disease Rating Scale. Reduced fractional anisotropy (P < .05, corrected) was found in PD subjects in regions related to the precentral gyrus, substantia nigra, putamen, posterior striatum, frontal lobe, and the supplementary motor areas. Reduced fractional anisotropy in the substantia nigra correlated (P < .05, corrected) with the increased rating scale motor scores. Significant spatial correlations between fractional anisotropy alterations in the putamen and other PD-affected regions were also found in the context of PD subtypes index analysis. Our data suggest that microstructural alterations detected with diffusion tensor might serve as a potential biomarker for PD. © 2011 Movement Disorder Society

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