Review

Deep brain stimulation in the treatment of chorea

  1. Thomas C. Edwards1,
  2. Ludvic Zrinzo1,2,
  3. Patricia Limousin1,
  4. Tom Foltynie1,*

Article first published online: 13 OCT 2011

DOI: 10.1002/mds.23967

Issue

Movement Disorders

Movement Disorders

Volume 27, Issue 3, pages 357–363, March 2012

Additional Information

How to Cite

Edwards, T. C., Zrinzo, L., Limousin, P. and Foltynie, T. (2012), Deep brain stimulation in the treatment of chorea. Mov. Disord., 27: 357–363. doi: 10.1002/mds.23967

Author Information

  1. 1

    Sobell Department of Motor Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG

  2. 2

    Victor Horsley Department of Neurosurgery, National Hospital for Neurology & Neurosurgery, Queen Square, London, WC1N 3BG

*Sobell Department of Motor Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG

Publication History

  1. Issue published online: 12 MAR 2012
  2. Article first published online: 13 OCT 2011

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Keywords:

  • Deep brain stimulation;
  • Huntington's disease;
  • Neuroacanthocytosis;
  • Choreiform disorders

Abstract

Deep brain stimulation has been used as a means of reducing dyskinesias in various conditions, including Parkinson's disease and dystonia for many years. Recently, owing to the clinical similarities between L-dopa induced dyskinesia and chorea, deep brain stimulation has now been implemented as a novel treatment method in both Huntington's disease and neuroacanthocytosis, and a paucity of case studies exist reporting its efficacy. This review will summarize the case studies of deep brain stimulation in both Huntington's disease and neuroacanthocytosis, and discuss the possible implications and limitations associated with these reports. As both these disorders are often refractory to medication and difficult to treat, deep brain stimulation may be a useful treatment option in the future. © 2011 Movement Disorder Society

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