Karin Srulijes and Matthias Reimold contributed equally to this work.
Fluorodeoxyglucose positron emission tomography in Richardson's syndrome and progressive supranuclear palsy-parkinsonism†
Article first published online: 5 OCT 2011
Copyright © 2011 Movement Disorder Society
Volume 27, Issue 1, pages 151–155, January 2012
How to Cite
Srulijes, K., Reimold, M., Liscic, R. M., Bauer, S., Dietzel, E., Liepelt-Scarfone, I., Berg, D. and Maetzler, W. (2012), Fluorodeoxyglucose positron emission tomography in Richardson's syndrome and progressive supranuclear palsy-parkinsonism. Mov. Disord., 27: 151–155. doi: 10.1002/mds.23975
Relevant conflicts of interest/financial disclosures: Nothing to report. Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 13 JAN 2012
- Article first published online: 5 OCT 2011
- Manuscript Accepted: 7 SEP 2011
- Manuscript Revised: 28 AUG 2011
- Manuscript Received: 17 MAR 2011
- positron emission tomography;
- postural instability;
- progressive supranuclear palsy
We hypothesized that postural instability and cognitive decline in patients with Richardson's syndrome could be a consequence of reduced thalamic and frontal metabolism. Severe Parkinsonian signs in patients with progressive supranuclear palsy-parkinsonism may be reflected by alterations in putaminal metabolism.
Eleven patients with Richardson's syndrome, 8 patients with progressive supranuclear palsy-parkinsonism, 12 with Parkinson's disease, and 10 controls underwent clinical assessment and fluorodeoxyglucose positron emission tomography (PET).
Richardson's syndrome patients showed pronounced thalamic hypometabolism, and patients with progressive supranuclear palsy-parkinsonism pronounced putaminal hypometabolism, compared to all other investigated groups. The putamen/thalamus uptake ratio differentiated progressive supranuclear palsy-parkinsonism from Richardson's syndrome (area under the curve = 0.86) and from Parkinson's disease (area under the curve = 0.80) with acceptable accuracy. Frontal hypometabolism was predominantly found in Richardson's syndrome patients.
Richardson's syndrome, progressive supranuclear palsy-parkinsonism and Parkinson's disease showed different metabolic patterns in fluorodeoxyglucose PET. © 2011 Movement Disorder Society