Funding agencies: The work was supported by the German research foundation (DFG JA 1087/1-1) and the German Hertie Foundation.
Article first published online: 13 OCT 2011
Copyright © 2011 Movement Disorder Society
Volume 27, Issue 1, pages 125–131, January 2012
How to Cite
Schniepp, R., Wuehr, M., Neuhaeusser, M., Kamenova, M., Dimitriadis, K., Klopstock, T., Strupp, M., Brandt, T. and Jahn, K. (2012), Locomotion speed determines gait variability in cerebellar ataxia and vestibular failure. Mov. Disord., 27: 125–131. doi: 10.1002/mds.23978
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 13 JAN 2012
- Article first published online: 13 OCT 2011
- Manuscript Accepted: 8 SEP 2011
- Manuscript Revised: 29 AUG 2011
- Manuscript Received: 19 OCT 2010
- gait analysis;
- gait variability;
- gait speed;
- bilateral vestibulopathy;
- cerebellar ataxia
Temporal gait variability is a critical parameter in patients with balance problems. Increased magnitude of temporal gait variability corresponds to a higher risk of falls. The purpose of this study was to investigate the influence of walking speed on temporal stride-to-stride variability in patients with cerebellar and vestibular deficits. A GAITRite system was used to analyze the gait of 40 patients with cerebellar ataxia, 22 patients with bilateral vestibular failure, and 51 healthy subjects over the entire range of the individual's speed capacity. The coefficient of variability of stride time was calculated for each walk. Temporal gait variability was increased in cerebellar patients and vestibular patients. The magnitude of this variability depended on walking speed in a disease-specific manner. In patients with cerebellar ataxia, variability was increased during slow (8.4 ± 5.3%, P < .01) and fast (7.9 ± 6.4%, P < .01) walking speed but was normal during preferred walking speed. This resulted in a speed-related U-shaped function of stride-time variability. Patients with vestibular failure had increased variability during slow walking (9.9 ± 4.3%, P < .01). During walking with medium and fast walking speed, stride time variability was normal. Minimal temporal gait variability appears to be attractive for the locomotor system in cerebellar patients because these patients preferred to walk at a velocity associated with minimal stride-time variability. In contrast to previous studies, vestibular patients accelerate rather than decelerate gait to achieve dynamic stability. This may be explained by reduced sensory integration during fast locomotion. © 2011 Movement Disorder Society