Dr. Janssen and Dr. Zwartjes contributed equally to this work.
Article first published online: 30 DEC 2011
Copyright © 2011 Movement Disorder Society
Volume 27, Issue 3, pages 435–438, March 2012
How to Cite
Janssen, M. L.F., Zwartjes, D. G.M., Temel, Y., van Kranen-Mastenbroek, V., Duits, A., Bour, L. J., Veltink, P. H., Heida, T. and Visser-Vandewalle, V. (2012), Subthalamic neuronal responses to cortical stimulation. Mov. Disord., 27: 435–438. doi: 10.1002/mds.24053
Funding agencies: BrainGain Smart Mix Program of the Netherlands Ministry of Economic Affairs and the Netherlands Ministry of Education, Culture and Science (grant number SSM06011).
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 12 MAR 2012
- Article first published online: 30 DEC 2011
- Manuscript Accepted: 31 OCT 2011
- Manuscript Revised: 21 OCT 2011
- Manuscript Received: 19 JUL 2011
- cortical stimulation;
- deep brain stimulation;
- Parkinson's disease;
- subthalamic nucleus
Deep brain stimulation of the subthalamic nucleus alleviates motor symptoms in Parkinson's disease patients. However, some patients suffer from cognitive and emotional changes. These side effects are most likely caused by current spread to the cognitive and limbic territories in the subthalamic nucleus. The aim of this study was to identify the motor part of the subthalamic nucleus to reduce stimulation-induced behavioral side effects, by using motor cortex stimulation.
We describe the results of subthalamic nucleus neuronal responses to stimulation of the hand area of the motor cortex and evaluate the safety of this novel technique.
Responses differed between regions within the subthalamic nucleus. In the anterior and lateral electrode at dorsal levels of the subthalamic nucleus, an early excitation (∼5–45 ms) and subsequent inhibition (45–105 ms) were seen. The lateral electrode also showed a late excitation (∼125–160 ms). Focal seizures were observed following motor cortex stimulation.
To prevent seizures the current density should be lowered, so that motor cortex stimulation-evoked responses can be safely used during deep brain stimulation surgery. © 2011 Movement Disorder Society