Review

Prevalence of pain in Parkinson's disease: A systematic review using the modified QUADAS tool†‡

  1. Martijn P.G. Broen MD1,*,
  2. Meriam M. Braaksma MD1,
  3. J. Patijn MD, PhD2,
  4. Wim E.J. Weber MD, PhD1

Article first published online: 9 JAN 2012

DOI: 10.1002/mds.24054

Issue

Movement Disorders

Movement Disorders

Volume 27, Issue 4, pages 480–484, April 2012

Additional Information

How to Cite

Broen, M. P.G., Braaksma, M. M., Patijn, J. and Weber, W. E.J. (2012), Prevalence of pain in Parkinson's disease: A systematic review using the modified QUADAS tool. Mov. Disord., 27: 480–484. doi: 10.1002/mds.24054

Author Information

  1. 1

    Section of Movement Disorders, Department of Neurology, Maastricht University Medical Centre, Maastricht, The Netherlands

  2. 2

    Department of Anaesthesiology, Maastricht University Medical Centre, Maastricht, The Netherlands

*Section of Movement Disorders, Department of Neurology, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands

  1. †

    Relevant conflicts of interest/financial disclosures: Nothing to report.

  2. ‡

    Full financial disclosures and author roles may be found in the online version of this article.

Publication History

  1. Issue published online: 4 APR 2012
  2. Article first published online: 9 JAN 2012
  3. Manuscript Accepted: 31 OCT 2011
  4. Manuscript Revised: 23 OCT 2011
  5. Manuscript Received: 9 MAY 2011

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Keywords:

  • pain;
  • Parkinson's disease;
  • prevalence

Abstract

Pain has been studied more intensely as a symptom of Parkinson's disease (PD) in recent years. However, studies on the characteristics and prevalence of pain in PD have yielded conflicting results, prompting us to do a systematic review of the literature. A systematic review of the literature was conducted, using different databases. The last inclusion date was March 15, 2011. The modified Quality Assessment of Diagnostic Accuracy Studies (QUADAS) tool was used, which is especially designed for judging prevalence studies on their methodological quality. Only articles that met the predefined criteria were used in this review. We found 18 articles, of which only 8 met the methodological criteria. Prevalence frequency ranges from 40% to 85% with a mean of 67.6%. Pain is most frequently located in the lower limbs, with almost one-half of all PD patients complaining about musculoskeletal pain (46.4%). The pain fluctuates with on-off periods. Surprisingly, only 52.4% of PD patients with pain used analgesics, most often nonopioids. PD patients seem to be predisposed to develop pain and physicians should be aware of pain as a common feature of PD. As many as one-half of PD patients with pain may be missing out on a potentially useful treatment, and proper treatment could increase quality of life in PD patients. © 2012 Movement Disorder Society

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