Funding agencies: Junta de Castilla y León grant, 2008.
Article first published online: 9 DEC 2011
Copyright © 2011 Movement Disorder Society
Volume 27, Issue 3, pages 439–442, March 2012
How to Cite
Cubo, E., González, M., del Puerto, I., de Yébenes, J. G., Arconada, O. F., Gabriel y Galán, J. M. T. and on behalf of the European Huntington's Disease Initiative Study Group (2012), Placebo effect characteristics observed in a single, international, longitudinal study in Huntington's disease. Mov. Disord., 27: 439–442. doi: 10.1002/mds.24062
Relevant conflicts of interest/financial disclosures: Nothing to report. Full financial disclosures and author roles may be found in the online version of this article.
Members of the European Huntington's Disease Initiative Study Group are listed in the Appendix.
- Issue published online: 12 MAR 2012
- Article first published online: 9 DEC 2011
- Manuscript Accepted: 11 NOV 2011
- Manuscript Revised: 4 NOV 2011
- Manuscript Received: 30 DEC 2010
- clinical trials;
- Huntington's disease;
- movement disorders;
Classically, clinical trials are based on the placebo-control design. Our aim was to analyze the placebo effect in Huntington's disease.
Placebo data were obtained from an international, longitudinal, placebo-controlled trial for Huntington's disease (European Huntington's Disease Initiative Study Group). One-hundred and eighty patients were evaluated using the Unified Huntington Disease Rating Scale over 36 months. A placebo effect was defined as an improvement of at least 50% over baseline scores in the Unified Huntington Disease Rating Scale, and clinically relevant when at least 10% of the population met it.
Only behavior showed a significant placebo effect, and the proportion of the patients with placebo effect ranged from 16% (first visit) to 41% (last visit). Nondepressed patients with better functional status were most likely to be placebo-responders over time.
In Huntington's disease, behavior seems to be more vulnerable to placebo than overall motor function, cognition, and function © 2011 Movement Disorder Society