Relevant conflicts of interest/financial disclosures: Nothing to report.
Article first published online: 7 FEB 2012
Copyright © 2012 Movement Disorder Society
Volume 27, Issue 4, pages 565–569, April 2012
How to Cite
Vedam-Mai, V., Yachnis, A., Ullman, M., Javedan, S. P. and Okun, M. S. (2012), Postmortem observation of collagenous lead tip region fibrosis as a rare complication of DBS. Mov. Disord., 27: 565–569. doi: 10.1002/mds.24916
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 4 APR 2012
- Article first published online: 7 FEB 2012
- Manuscript Accepted: 1 JAN 2012
- Manuscript Revised: 20 DEC 2011
- Manuscript Received: 14 OCT 2011
- UF Foundation
- Jacobus Fund
- UF DBS Brain Tissue Network
- National Parkinson Foundation Center of Excellence
- DBS complications;
- adverse events;
Despite the widespread effective use of deep brain stimulation (DBS) for various movement and psychiatric disorders, little is known about its safety and tissue responses.
The University of Florida Deep Brain Stimulation Brain Tissue Network (DBS-BTN) conducted postmortem brain examinations on 26 cases to identify and characterize (using histological techniques) pathologic tissue changes associated with the placement of DBS devices.
We report the unusual finding of prominent collagenous fibrosis around the lead tip in a 74-year-old man with idiopathic Parkinson's disease who had bilateral STN-DBS. Histological study confirmed the diagnosis of idiopathic Parkinson's disease, and there was striking, dense collagenous fibrosis at the distal end of the right DBS lead associated with focal hemosiderin deposition, chronic inflammation, and mild gliosis. We have in our brain bank 25 other DBS cases that on examination showed only mild to moderate gliosis and no dramatic tissue response to DBS lead placement.
We are not aware of any prior reports of such a dramatic reaction to DBS placement to date. © 2012 Movement Disorder Society