Funding agencies: This study was funded by the NIH (RO1-NS32527, AGO7232, R01AG028506, P30 ES009089, 1UL1 RR024156-01) and the Parkinson's Disease Foundation.
Version of Record online: 7 FEB 2012
Copyright © 2012 Movement Disorder Society
Volume 27, Issue 6, pages 771–774, May 2012
How to Cite
Alcalay, R. N., Gu, Y., Mejia-Santana, H., Cote, L., Marder, K. S. and Scarmeas, N. (2012), The association between Mediterranean diet adherence and Parkinson's disease. Mov. Disord., 27: 771–774. doi: 10.1002/mds.24918
Relevant conflicts of interest/financial disclosures: Roy N. Alcalay is supported by the Brookdale Foundation Leadership in Aging Fellowship and the NIH (KL2 RR024157).
Full financial disclosures and author roles may be found in the online version of this article.
- Issue online: 30 MAY 2012
- Version of Record online: 7 FEB 2012
- Manuscript Accepted: 26 DEC 2011
- Manuscript Revised: 22 NOV 2011
- Manuscript Received: 15 JUL 2011
- Mediterranean diet;
- Parkinson's disease;
- dietary pattern
Recent studies have demonstrated an association between a Mediterranean-type diet and Alzheimer's risk. We assessed the association between Mediterranean-type diet adherence and Parkinson's disease (PD) status.
Two hundred and fifty-seven PD participants and 198 controls completed the Willett semiquantitative questionnaire that quantifies diet during the past year. Scores were calculated using a 9-point scale; higher scores indicated greater adherence to the Mediterranean-type diet. Logistic regression models were used to assess the association between PD status and Mediterranean-type diet, adjusting for caloric intake, age, sex, education, and ethnicity. Adjusted linear regression models were used to examine the association between Mediterranean-type diet adherence and PD age at onset.
Higher Mediterranean-type diet adherence was associated with reduced odds for PD after adjustment for all covariates (OR, 0.86; 95% CI, 0.77–0.97; P = .010). Lower Mediterranean-type diet score was associated with earlier PD age at onset (β = 1.09; P = .006).
PD patients adhere less than controls to a Mediterranean-type diet. Dietary behavior may be associated with age at onset. © 2012 Movement Disorder Society