The association between Mediterranean diet adherence and Parkinson's disease§

Authors

  • Roy N. Alcalay MD, MSc,

    Corresponding author
    1. Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    2. Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    • Columbia University. Neurology, 710 West 168th Street, 3rd floor, New York, NY 10032
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  • Yian Gu PhD,

    1. Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA
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  • Helen Mejia-Santana MSc,

    1. Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
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  • Lucien Cote MD,

    1. Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    2. Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
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  • Karen S. Marder MD, MPH,

    1. Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    2. Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    3. Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    4. Department of Psychiatry, Columbia University Medical Center, New York, New York, USA
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  • Nikolaos Scarmeas MD, MS

    1. Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    2. Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    3. Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
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  • Funding agencies: This study was funded by the NIH (RO1-NS32527, AGO7232, R01AG028506, P30 ES009089, 1UL1 RR024156-01) and the Parkinson's Disease Foundation.

  • Relevant conflicts of interest/financial disclosures: Roy N. Alcalay is supported by the Brookdale Foundation Leadership in Aging Fellowship and the NIH (KL2 RR024157).

  • §

    Full financial disclosures and author roles may be found in the online version of this article.

Abstract

Background:

Recent studies have demonstrated an association between a Mediterranean-type diet and Alzheimer's risk. We assessed the association between Mediterranean-type diet adherence and Parkinson's disease (PD) status.

Methods:

Two hundred and fifty-seven PD participants and 198 controls completed the Willett semiquantitative questionnaire that quantifies diet during the past year. Scores were calculated using a 9-point scale; higher scores indicated greater adherence to the Mediterranean-type diet. Logistic regression models were used to assess the association between PD status and Mediterranean-type diet, adjusting for caloric intake, age, sex, education, and ethnicity. Adjusted linear regression models were used to examine the association between Mediterranean-type diet adherence and PD age at onset.

Results:

Higher Mediterranean-type diet adherence was associated with reduced odds for PD after adjustment for all covariates (OR, 0.86; 95% CI, 0.77–0.97; P = .010). Lower Mediterranean-type diet score was associated with earlier PD age at onset (β = 1.09; P = .006).

Conclusions:

PD patients adhere less than controls to a Mediterranean-type diet. Dietary behavior may be associated with age at onset. © 2012 Movement Disorder Society

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