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Keywords:

  • α-synuclein;
  • autonomic nervous system;
  • enteric nervous system;
  • incidental Lewy body disease;
  • Lewy body disease;
  • neurodegeneration;
  • neuron-to-neuron transmission;
  • Parkinson's disease;
  • Lewy neurites/bodies;
  • PARS;
  • premotor Parkinson's disease;
  • sporadic Parkinson's disease;
  • spinal cord;
  • superior cervical ganglion

Abstract

The foremost motor manifestations of Parkinson's disease are resting tremor, cogwheel rigidity, hypokinesia/bradykinesia, and postural instability. Epidemiological and clinical data reveal that a wide variety of additional complaints (nonmotor symptoms), also considerably impar patients' quality of life parallel to the chronic-progressive neurodegenerative disorder. This article reviews the neuropathology and anatomy of Lewy pathology-related neurodegeneration in relation to selected nonmotro and prodromal dysfunctions. © 2012 Movement Disorder Society