Lewy pathology and neurodegeneration in premotor Parkinson's disease§

Authors

  • Kelly Del Tredici MD, PhD,

    Corresponding author
    1. Clinical Neuroanatomy Section, Department of Neurology, Center for Biomedical Research, University of Ulm, Ulm, Germany
    • Clinical Neuroanatomy Section, Department of Neurology, Center for Biomedical Research, University of Ulm, Helmholtzstrasse 8/1, 89081 Ulm, Germany
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  • Heiko Braak MD

    1. Clinical Neuroanatomy Section, Department of Neurology, Center for Biomedical Research, University of Ulm, Ulm, Germany
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  • Funding agencies: Funding for this article was provided by the German Research Council (Deutsche Forschungsgemeinschaft, DFG) and the Michael J. Fox Foundation for Parkinson's Disease Research (New York, NY). The Braak Collection (Goethe University Frankfurt, Frankfurt, Germany) provided tissue.

  • Relevant conflicts of interest/financialdisclosures: Nothing to report.

  • §

    Full financial disclosures and author roles may be found in the online version of this article.

Abstract

The foremost motor manifestations of Parkinson's disease are resting tremor, cogwheel rigidity, hypokinesia/bradykinesia, and postural instability. Epidemiological and clinical data reveal that a wide variety of additional complaints (nonmotor symptoms), also considerably impar patients' quality of life parallel to the chronic-progressive neurodegenerative disorder. This article reviews the neuropathology and anatomy of Lewy pathology-related neurodegeneration in relation to selected nonmotro and prodromal dysfunctions. © 2012 Movement Disorder Society

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