Relevant conflicts of interest/financial disclosures: Nothing to report.
Article first published online: 16 APR 2012
Copyright © 2012 Movement Disorder Society
Special Issue: Prodromal Parkinson's Disease
Volume 27, Issue 5, pages 634–643, 15 April 2012
How to Cite
Godau, J., Hussl, A., Lolekha, P., Stoessl, A. J. and Seppi, K. (2012), Neuroimaging: Current role in detecting pre-motor Parkinson's disease. Mov. Disord., 27: 634–643. doi: 10.1002/mds.24976
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 16 APR 2012
- Article first published online: 16 APR 2012
- Manuscript Accepted: 26 FEB 2012
- Manuscript Revised: 1 FEB 2012
- Manuscript Received: 26 SEP 2011
- Parkinson's disease
Convergent evidence suggests a pre-motor period in Parkinson's disease (PD) during which typical motor symptoms have not yet developed although dopaminergic neurons in the substantia nigra have started to degenerate. Advances in different neuroimaging techniques have allowed the detection of functional and structural changes in early PD. This review summarizes the state of the art knowledge concerning structural neuroimaging techniques including magnetic resonance imaging (MRI) and transcranial B-mode-Doppler-sonography (TCS) as well as functional neuroimaging techniques using radiotracer imaging (RTI) with different radioligands in detecting pre-motor PD. © 2012 Movement Disorder Society