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C9ORF72 expansion in amyotrophic lateral sclerosis/frontotemporal dementia also causes parkinsonism§

Authors

  • Seán O'Dowd MRCPI,

    1. Laboratory for Neurodegenerative Research, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
    2. Dublin Neurological Institute at the Mater Misericordiae University Hospital, Dublin, Ireland
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    • These authors contributed equally.

  • Denis Curtin MRCPI,

    1. Dublin Neurological Institute at the Mater Misericordiae University Hospital, Dublin, Ireland
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    • These authors contributed equally.

  • Adrian J. Waite PhD,

    1. MRC Center for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, UK
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  • Kinley Roberts MRCPI,

    1. Dublin Neurological Institute at the Mater Misericordiae University Hospital, Dublin, Ireland
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  • Niall Pender PhD,

    1. Department of Neuropsychology, Beaumont Hospital, Dublin, Ireland
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  • Valerie Reid MRCPI,

    1. Department of Neurophysiology, Mater Misericordiae University Hospital, Dublin, Ireland
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  • Martin O'Connell MD,

    1. Department of Radiology, Mater Misericordiae University Hospital, Dublin, Ireland
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  • Nigel M. Williams PhD,

    1. MRC Center for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, UK
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  • Huw R. Morris MD,

    1. MRC Center for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, UK
    2. Neurology (C4), University Hospital of Wales, Cardiff, UK
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  • Bryan J. Traynor MD,

    1. Neuromuscular Diseases Research Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    2. Department of Neurology, Brain Sciences Institute, Johns Hopkins Hospital, Baltimore Maryland, USA
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  • Timothy Lynch FRCPI

    Corresponding author
    1. Laboratory for Neurodegenerative Research, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
    2. Dublin Neurological Institute at the Mater Misericordiae University Hospital, Dublin, Ireland
    • Dublin Neurological Institute at Mater University Hospital, Eccles Street, Dublin 7, Dublin, Ireland
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  • Funding agencies: This work was supported by The Motor Neuron Disease Association (grant no.: 8047), The Irish Institute of Clinical Neuroscience, and the Mater College of Postgraduate Research, Dublin.

  • This work was funded in part by the Intramural Research Program of the NIH, National Institute on Aging (Z01-AG000949-02) and NINDS. Bryan J. Traynor was funded by the ALS Association, The Packard Center for ALS Research, FIGC, and The Myasthenia Gravis Foundation. A patent is pending for C9ORF72, with Bryan J. Traynor, Nigel M. Williams, and Huw R. Morris listed as inventors.

  • §

    Relevant conflicts of interest/financial disclosures: Timothy Lynch has received educational grants from Bayer-Schering, Biogen, Boerhinger-Ingelheim, Lundbeck, Orion and Merck Serona; and for payment for advisory boards and lectures from Abbott, Biogen, Lundbeck, Novartis and UCB.

  • Full financial disclosures and author roles may be found in the online version of this article.

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