Research Article

Alcohol and risk of Parkinson's disease in a large, prospective cohort of men and women†‡

  1. Natalia Palacios PhD1,*,
  2. Xiang Gao MD, PhD1,5,
  3. Eilis O'Reilly PhD1,
  4. Michael Schwarzschild2,
  5. Marjorie L. McCullough ScD3,
  6. Tinisha Mayo3,
  7. Susan M. Gapstur PhD3,
  8. Alberto A. Ascherio PhD1,4,5

Article first published online: 19 JUN 2012

DOI: 10.1002/mds.25050

Issue

Movement Disorders

Movement Disorders

Volume 27, Issue 8, pages 980–987, July 2012

Additional Information

How to Cite

Palacios, N., Gao, X., O'Reilly, E., Schwarzschild, M., McCullough, M. L., Mayo, T., Gapstur, S. M. and Ascherio, A. A. (2012), Alcohol and risk of Parkinson's disease in a large, prospective cohort of men and women. Mov. Disord., 27: 980–987. doi: 10.1002/mds.25050

Author Information

  1. 1

    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA

  2. 2

    Massachusetts General Hospital, Boston, Massachusetts, USA

  3. 3

    Epidemiology Research Program, Atlanta, Georgia, USA

  4. 4

    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA

  5. 5

    Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA

*Department of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115

  1. †

    Relevant conflicts of interest/financial disclosures: Nothing to report.

  2. ‡

    Full financial disclosures and author roles may be found in the online version of this article.

Publication History

  1. Issue published online: 17 JUL 2012
  2. Article first published online: 19 JUN 2012
  3. Manuscript Accepted: 20 APR 2012
  4. Manuscript Revised: 23 MAR 2012
  5. Manuscript Received: 27 SEP 2011

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Keywords:

  • Parkinson;
  • alcohol;
  • epidemiology;
  • cohort;
  • prospective

Abstract

Addictive behaviors, such as cigarette smoking and coffee drinking, have been associated with a reduced risk of Parkinson's disease (PD). Whether alcohol consumption is also associated with PD risk is less certain. We prospectively followed 132,403 participants in the Cancer Prevention Study II Nutrition Cohort from 1992 to 2005. Alcohol intake was assessed at baseline. Incident cases of PD (n = 605; 389 male and 216 female) were confirmed by treating physicians and medical record review. Relative risks (RRs) were estimated using proportional hazards models, adjusting for age, smoking, and other risk factors. Alcohol consumption was not significantly associated with PD risk. After adjustment for age, smoking, and other risk factors, the RR comparing men consuming 30 or more grams of alcohol per day (highest category) to nondrinker men was 1.29 (95% confidence interval [CI]: 0.90, 1.86; P trend: 0.40), and the RR comparing women consuming 15 or more grams of alcohol (highest category) per day to nondrinker women was 0.77 (95% CI: 0.41, 1.45; P trend: 0.87). Consumption of beer, wine, or liquor was also not associated with PD risk. The results of this large, prospective study do not support an association between alcohol intake and risk of PD. © 2012 Movement Disorder Society

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