Weight variation before and after surgery in Parkinson's disease: A noradrenergic modulation?

Authors

  • Joana Guimarães,

    Corresponding author
    1. Neurology Department, Faculty of Medicine, University of Porto, Hospital de São João, Porto, Portugal
    2. Instituto de Biologia Molecular e Celular, Porto, Portugal
    • Neurology Department, Faculty of Medicine, University of Porto, Hospital de São João, Alameda Professor Hernâni Monteiro, 4200, Porto, Portugal
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  • Eduardo Moura,

    1. Instituto de Biologia Molecular e Celular, Porto, Portugal
    2. Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Hospital de São João, Porto, Portugal
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  • Maria Augusta Vieira-Coelho,

    1. Instituto de Biologia Molecular e Celular, Porto, Portugal
    2. Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Hospital de São João, Porto, Portugal
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  • Carolina Garrett

    1. Neurology Department, Faculty of Medicine, University of Porto, Hospital de São João, Porto, Portugal
    2. Instituto de Biologia Molecular e Celular, Porto, Portugal
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  • Relevant conflicts of interest/financial disclosures: Nothing to report.

  • Full financial disclosures and author roles may be found in the online version of this article.

Abstract

Changes in the nutritional profile of patients with Parkinson's disease have been reported before and after deep brain stimulation surgery. The major determinants of the weight variation in Parkinson's disease are not yet understood, and the mechanism seems complex. Based on the influence of the sympathetic nervous system in metabolic syndrome obesity, the intent of the present review is to consider the role of noradrenergic modulation on weight variations in Parkinson's disease. In this review the authors raise the following hypothesis: weight variation in Parkinson's disease before and after deep brain stimulation of the subthalamic nucleus could be influenced by noradrenergic interaction between the locus coeruleus, subthalamic nucleus, and hypothalamic nucleus. © 2012 Movement Disorder Society

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