Impairment of brain vessels may contribute to mortality in patients with Parkinson's disease§

Authors

  • Ivan Rektor MD, CSc,

    Corresponding author
    1. Central European Institute of Technology, Brno, Czech Republic
    2. Movement Disorders and Stroke Centers, First Department of NeurologySt. Anne's Teaching Hospital, Brno, Czech Republic
    • First Department of Neurology, Masaryk University, St. Anne's Hospital, Pekarska 53, 656 91 Brno, Czech Republic
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  • David Goldemund MD,

    1. Movement Disorders and Stroke Centers, First Department of NeurologySt. Anne's Teaching Hospital, Brno, Czech Republic
    2. International Clinical Research Center, Brno, Czech Republic
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  • Petr Bednařík MD,

    1. Central European Institute of Technology, Brno, Czech Republic
    2. Department of Imaging Methods, Masaryk University, St. Anne's Teaching Hospital, Brno, Czech Republic
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  • Kateřina Sheardová MD,

    1. Movement Disorders and Stroke Centers, First Department of NeurologySt. Anne's Teaching Hospital, Brno, Czech Republic
    2. International Clinical Research Center, Brno, Czech Republic
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  • Zuzana Michálková PhD,

    1. Movement Disorders and Stroke Centers, First Department of NeurologySt. Anne's Teaching Hospital, Brno, Czech Republic
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  • Sabina Telecká PhD,

    1. Central European Institute of Technology, Brno, Czech Republic
    2. Movement Disorders and Stroke Centers, First Department of NeurologySt. Anne's Teaching Hospital, Brno, Czech Republic
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  • Michal Dufek MD,

    1. Movement Disorders and Stroke Centers, First Department of NeurologySt. Anne's Teaching Hospital, Brno, Czech Republic
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  • Irena Rektorová MD, PhD

    1. Central European Institute of Technology, Brno, Czech Republic
    2. Movement Disorders and Stroke Centers, First Department of NeurologySt. Anne's Teaching Hospital, Brno, Czech Republic
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  • Funding agencies: The study was supported by Research Program MSM0021622404 and the Central European Institute of Technology.

  • Relevant conflicts of interest/financial disclosures: Nothing to report.

  • §

    Full financial disclosures and author roles may be found in the online version of this article.

Abstract

Background:

The effect of brain-vessel pathology on mortality in 57 consecutive PD patients was studied.

Methods:

Baseline clinical, neuropsychological, ultrasonographic (US), and MR data obtained from patients who died (n = 18) during a 4-year follow-up period were compared with the data of patients who survived.

Results:

US/MRI data displayed a more-severe vascular impairment in deceased patients. Differences were significant between both groups with respect to age, clinical and cognitive status, intima-media thickness, and resistance index (indicators of large and small vessel impairment). The sum score of white-matter hyperintensities was significantly higher among decedents. A cluster analysis displayed two clusters that differed in the two parameters (i.e. in age and in sum score).

Conclusions:

This study provides evidence that comorbid atherosclerosis and otherwise subclinical impairment of brain vessels may contribute to mortality in PD. The vascular pathology may act in association with other comorbidities on the terrain of progressive neurodegenerative pathology. © 2012 Movement Disorder Society

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