Funding agencies: The study was supported by Research Program MSM0021622404 and the Central European Institute of Technology.
Article first published online: 12 JUN 2012
Copyright © 2012 Movement Disorder Society
Volume 27, Issue 9, pages 1169–1172, August 2012
How to Cite
Rektor, I., Goldemund, D., Bednařík, P., Sheardová, K., Michálková, Z., Telecká, S., Dufek, M. and Rektorová, I. (2012), Impairment of brain vessels may contribute to mortality in patients with Parkinson's disease. Mov. Disord., 27: 1169–1172. doi: 10.1002/mds.25066
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 3 AUG 2012
- Article first published online: 12 JUN 2012
- Manuscript Accepted: 25 APR 2012
- Manuscript Received: 18 APR 2012
- cerebrovascular disease;
- Parkinson's disease;
The effect of brain-vessel pathology on mortality in 57 consecutive PD patients was studied.
Baseline clinical, neuropsychological, ultrasonographic (US), and MR data obtained from patients who died (n = 18) during a 4-year follow-up period were compared with the data of patients who survived.
US/MRI data displayed a more-severe vascular impairment in deceased patients. Differences were significant between both groups with respect to age, clinical and cognitive status, intima-media thickness, and resistance index (indicators of large and small vessel impairment). The sum score of white-matter hyperintensities was significantly higher among decedents. A cluster analysis displayed two clusters that differed in the two parameters (i.e. in age and in sum score).
This study provides evidence that comorbid atherosclerosis and otherwise subclinical impairment of brain vessels may contribute to mortality in PD. The vascular pathology may act in association with other comorbidities on the terrain of progressive neurodegenerative pathology. © 2012 Movement Disorder Society