Funding agencies: This work was funded by the VA Parkinson's Disease Research, Education, and Care Consortium.
Article first published online: 12 JUN 2012
Copyright © 2012 Movement Disorder Society
Volume 27, Issue 9, pages 1125–1128, August 2012
How to Cite
Lessig, S., Nie, D., Xu, R. and Corey-Bloom, J. (2012), Changes on brief cognitive instruments over time in Parkinson's disease. Mov. Disord., 27: 1125–1128. doi: 10.1002/mds.25070
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 3 AUG 2012
- Article first published online: 12 JUN 2012
- Manuscript Accepted: 8 MAY 2012
- Manuscript Revised: 30 APR 2012
- Manuscript Received: 6 MAR 2012
- Parkinson's Disease;
Two hundred and twenty-one subjects with Parkinson's disease (PD) were examined using the Mini–Mental Status Examination (MMSE) and Montreal Cognitive Assessment (MoCA), with a subset of these (n = 98) examined on repeat testing up to 3 years. The MoCA was more sensitive in identifying cognitive deficit, specifically in the domains of visuospatial abilities, language, and memory. In longitudinal study, the MMSE changed significantly over time, particularly in patients with disease duration of >10 years. The MoCA, however, did not change significantly, even when subjects were stratified by age, MMSE score, and disease duration. This suggests that the MoCA may be more sensitive for detecting early cognitive change in PD, but that the MMSE, and not the MoCA, may be better for tracking cognitive decline. © 2012 Movement Disorder Society