Brief Report

Enhanced low-frequency oscillatory activity of the subthalamic nucleus in a patient with dystonia†‡

  1. Wolf-Julian Neumann1,
  2. Julius Huebl MD1,
  3. Christof Brücke MD1,
  4. Maria Herrojo Ruiz PhD1,
  5. Andreas Kupsch MD1,
  6. Gerd-Helge Schneider MD2,
  7. Andrea A. Kühn MD1,*

Article first published online: 14 JUN 2012

DOI: 10.1002/mds.25078

Issue

Movement Disorders

Movement Disorders

Volume 27, Issue 8, pages 1063–1066, July 2012

Additional Information

How to Cite

Neumann, W.-J., Huebl, J., Brücke, C., Ruiz, M. H., Kupsch, A., Schneider, G.-H. and Kühn, A. A. (2012), Enhanced low-frequency oscillatory activity of the subthalamic nucleus in a patient with dystonia. Mov. Disord., 27: 1063–1066. doi: 10.1002/mds.25078

Author Information

  1. 1

    Department of Neurology, Charité University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany

  2. 2

    Department of Neurosurgery, Charité University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany

*Department of Neurology, Charité—University Medicine Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany

  1. †

    Relevant conflicts of interest/financial disclosures: Nothing to report.

  2. ‡

    Full financial disclosures and author roles may be found in the online version of this article.

Publication History

  1. Issue published online: 17 JUL 2012
  2. Article first published online: 14 JUN 2012
  3. Manuscript Accepted: 13 MAY 2012
  4. Manuscript Revised: 6 MAR 2012
  5. Manuscript Received: 23 NOV 2011

Funded by

  • Else-Kröner-Fresenius Foundation. Grant Number: EKMS 08/22
  • DFG. Grant Number: KFO 247

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Keywords:

  • dystonia;
  • basal ganglia;
  • deep brain stimulation;
  • local field potential;
  • oscillatory activity

Abstract

Background:

Local field potentials were recorded from the subthalamic nucleus (STN) in a patient with dystonia to further elucidate disease-specific aspects of basal ganglia oscillatory activity.

Methods:

STN local field potentials and electromyograms (EMGs) from dystonic muscles were recorded to provide an estimate of the power spectra and coherence between the STN activity and EMG.

Results:

STN power spectra revealed a distinct peak at approximately 7 Hz in our patient. This finding is similar to the pallidal activity seen in dystonic patients but clearly different from the subthalamic beta activity of patients with Parkinson's disease. Significant coherence between STN activity and EMG was present in the 4- to 12-Hz band in this patient.

Conclusions:

Dystonia is associated with pathological activity in the theta range present throughout the cortical-basal ganglia network. This activity differs from that in Parkinson's disease, suggesting that different movement disorders may involve distinct oscillatory circuit disturbances. © 2012 Movement Disorder Society

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