Funding agencies: This study was supported by grants from the Canadian Institutes of Health Research, the Parkinson Society of Canada, and by the Fonds de la Recherche en Santé du Québec.
Version of Record online: 25 JUN 2012
Copyright © 2012 Movement Disorder Society
Volume 27, Issue 8, pages 996–1003, July 2012
How to Cite
Romenets, S. R., Gagnon, J.-F., Latreille, V., Panniset, M., Chouinard, S., Montplaisir, J. and Postuma, R. B. (2012), Rapid eye movement sleep behavior disorder and subtypes of Parkinson's disease. Mov. Disord., 27: 996–1003. doi: 10.1002/mds.25086
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue online: 17 JUL 2012
- Version of Record online: 25 JUN 2012
- Manuscript Accepted: 17 MAY 2012
- Manuscript Revised: 23 APR 2012
- Manuscript Received: 18 JAN 2012
- REM sleep behavior disorder;
- Parkinson's disease;
- orthostatic hypotension;
- motor manifestation;
- nonmotor manifestation
Numerous studies have explored the potential relationship between rapid eye movement sleep behavior disorder (RBD) and manifestations of PD. Our aim was to perform an expanded extensive assessment of motor and nonmotor manifestations in PD to identify whether RBD was associated with differences in the nature and severity of these manifestations. PD patients underwent polysomnography (PSG) to diagnose the presence of RBD. Participants then underwent an extensive evaluation by a movement disorders specialist blinded to PSG results. Measures of disease severity, quantitative motor indices, motor subtypes, therapy complications, and autonomic, psychiatric, visual, and olfactory dysfunction were assessed and compared using regression analysis, adjusting for disease duration, age, and sex. Of 98 included patients, 54 had RBD and 44 did not. PD patients with RBD were older (P = 0.034) and were more likely to be male (P < 0.001). On regression analysis, the most consistent links between RBD and PD were a higher systolic blood pressure (BP) change while standing (−23.9 ± 13.9 versus −3.5 ± 10.9; P < 0.001), a higher orthostatic symptom score (0.89 ± 0.82 versus 0.44 ± 0.66; P = 0.003), and a higher frequency of freezing (43% versus14%; P = 0.011). A systolic BP drop >10 could identify PD patients with RBD with 81% sensitivity and 86% specificity. In addition, there was a probable relationship between RBD and nontremor predominant subtype of PD (P = 0.04), increased frequency of falls (P = 0.009), and depression (P = 0.009). Our results support previous findings that RBD is a multifaceted phenomenon in PD. Patients with PD who have RBD tend to have specific motor and nonmotor manifestations, especially orthostatic hypotension. © 2012 Movement Disorder Society