Subthalamic activity during diphasic dyskinesias in Parkinson's disease§

Authors

  • Manuel Alegre MD, PhD,

    Corresponding author
    1. Neurosciences Area, CIMA, University of Navarra, Pamplona, Spain
    2. Neurophysiology Section, Clínica Universidad de Navarra, Pamplona, Spain
    • Neurophysiology Laboratory (2.32/2.33), Neurosciences Area, CIMA, Avenida Pío XII, 55, 31008 Pamplona, Spain
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  • Jon López-Azcárate PhD,

    1. Neurosciences Area, CIMA, University of Navarra, Pamplona, Spain
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  • Fernando Alonso-Frech MD, PhD,

    1. Department of Neurology and Neurosurgery, Clínica Universidad de Navarra, Pamplona, Spain
    Current affiliation:
    1. Department of Neurology, Hospital de Fuenlabrada, Fuenlabrada, Madrid, Spain
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  • Maria C. Rodríguez-Oroz MD, PhD,

    1. Neurosciences Area, CIMA, University of Navarra, Pamplona, Spain
    2. Department of Neurology and Neurosurgery, Clínica Universidad de Navarra, Pamplona, Spain
    Current affiliation:
    1. Department of Neurology, Hospital Donostia and Neuroscience Unit, BioDonostia Research Institute, San Sebastián, Spain; Ikerbasque, Basque Foundation for Science, Bilbao, Spain
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  • Miguel Valencia PhD,

    1. Neurosciences Area, CIMA, University of Navarra, Pamplona, Spain
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  • Jorge Guridi MD, PhD,

    1. Department of Neurology and Neurosurgery, Clínica Universidad de Navarra, Pamplona, Spain
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  • Julio Artieda MD, PhD,

    1. Neurosciences Area, CIMA, University of Navarra, Pamplona, Spain
    2. Neurophysiology Section, Clínica Universidad de Navarra, Pamplona, Spain
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  • José A. Obeso MD, PhD

    1. Neurosciences Area, CIMA, University of Navarra, Pamplona, Spain
    2. Department of Neurology and Neurosurgery, Clínica Universidad de Navarra, Pamplona, Spain
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  • Funding agencies: This work was partially funded by a grant from the Departamento de Salud, Gobierno de Navarra (Ref. 14/2009) and by “UTE proyecto CIMA.”

  • Relevant conflicts of interest/financial disclosures: Miguel Valencia acknowledges financial support from the Spanish Ministry of Science and Innovation, Juan de la Cierva Programme (Ref. JCI-2010-07876).

  • §

    Full financial disclosures and author roles may be found in the online version of this article.

Abstract

Background:

Diphasic dyskinesias are a subtype of levodopa-induced dyskinesias that appear typically at the onset and end of levodopa antiparkinsonian action. The pathophysiology of diphasic dyskinesias is not well understood.

Methods:

We analyzed local field potentials recorded from the subthalamic nucleus in 7 Parkinson's disease (PD) patients who showed typical diphasic dyskinesias during postoperative recordings through a deep brain stimulation electrode. The evolution of the different oscillatory activities related to the onset and end of diphasic dyskinesias was studied by windowed fast Fourier transforms.

Results:

Typical “off”-state beta activity disappeared with the onset of diphasic dyskinesias, whereas gamma activity was absent or minimal until their end. Theta activity during diphasic dyskinesias was similar to that observed during peak-dose dyskinesias.

Conclusions:

From a neurophysiological viewpoint, patients exhibited oscillatory activity typical of the “on” medication state during diphasic dyskinesias. The minimal presence of gamma activity during diphasic dyskinesias, however, suggests that this “on” state might be incomplete or limited to dopaminergic mechanisms affecting the lower limbs. © 2012 Movement Disorder Society

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