Relevant conflicts of interest/financial disclosures: Glenda M. Halliday is funded as a Senior Principal Research Fellow of the National Health and Medical Research Council of Australia to perform research.
Article first published online: 26 SEP 2012
Copyright © 2012 Movement Disorder Society
Volume 27, Issue 12, pages 1506–1512, October 2012
How to Cite
Schwartz, R. S., Halliday, G. M., Cordato, D. J. and Kril, J. J. (2012), Small-vessel disease in patients with Parkinson's disease: A clinicopathological study. Mov. Disord., 27: 1506–1512. doi: 10.1002/mds.25112
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 18 OCT 2012
- Article first published online: 26 SEP 2012
- Manuscript Accepted: 15 JUN 2012
- Manuscript Revised: 10 MAY 2012
- Manuscript Received: 6 MAR 2012
- vascular risk factors
Few studies have examined the relationship between cerebrovascular disease, vascular risk factors, and Parkinson's disease (PD), although 1 study found small-vessel disease (SVD) to be the main subtype of cerebrovascular disease. In this study we compared the extent and topography of SVD and assessed associated vascular risk factors in autopsy-proven PD cases and community-dwelling controls. Seventy-seven PD and 32 control brains from the Sydney Brain Bank were assessed microscopically by a single examiner blinded to the diagnosis. SVD was assessed by grading perivascular pallor, gliosis, hyaline thickening, and enlargement of perivascular spaces in the white matter underlying the superior frontal and primary motor cortices, basal ganglia, and white matter tracts. A history of vascular risk factors (hypertension, heart disease, diabetes, and cigarette smoking) was obtained. Groups were compared using stepwise multiple regression analysis. There was significantly greater frontal pallor (P = .004) and widening of perivascular spaces in the globus pallidus interna (P = .007) in controls compared with PD. Hyaline thickening and widening of perivascular spaces in the frontal white matter, hyaline thickening in the motor white matter, and widening of perivascular spaces in the caudate nucleus were more common in the control group, but did not reach significance. The prevalence of vascular risk factors and SVD pathology was significantly lower in autopsy-proven PD compared with controls (P = .03) living in the same community. The results of this study support the need for further research in this area. © 2012 Movement Disorder Society