Relevant conflicts of interest/financial disclosures: Igor N. Petrovic has received funding for this research from the Ministry of Science and Technology of the Republic of Serbia (project no. 175090) and a Prof Risto Bokonjic Foundation Research Fellowship.
Article first published online: 17 JUL 2012
Copyright © 2012 Movement Disorder Society
Volume 27, Issue 9, pages 1186–1190, August 2012
How to Cite
Petrovic, I. N., Ling, H., Asi, Y., Ahmed, Z., Kukkle, P. L., Hazrati, L.-N., Lang, A. E., Revesz, T., Holton, J. L. and Lees, A. J. (2012), Multiple system atrophy–parkinsonism with slow progression and prolonged survival: A diagnostic catch. Mov. Disord., 27: 1186–1190. doi: 10.1002/mds.25115
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 3 AUG 2012
- Article first published online: 17 JUL 2012
- Manuscript Accepted: 14 JUN 2012
- Manuscript Revised: 23 MAY 2012
- Manuscript Received: 24 JAN 2012
- multiple system atrophy;
- autonomic dysfunction;
- visual hallucination;
- slow progression
Multiple system atrophy (MSA) is a neurodegenerative disease leading to severe physical impairment, with a disease duration from onset to death of 6–9 years.
The clinical and neuropathological features of 4 MSA cases with disease duration of 15 years or more were analyzed.
All patients presented with parkinsonism and had a mean latency of 11 years before the development of dysautonomia. Mean duration from onset of first symptoms to anterocollis, inspiratory stridor, and dysphagia was 9 years. Despite the limited levodopa response, all patients developed levodopa-induced dyskinesia.
Late appearance of dysautonomia is a favorable prognostic factor in MSA-P. Greater awareness of this uncommon “benign” subgroup of MSA will improve diagnostic accuracy and help to more accurately inform treatment options. © 2012 Movement Disorder Society