Funding agencies: This study was funded by the Michael J. Fox Foundation for Parkinson's Research.
Article first published online: 1 AUG 2012
Copyright © 2012 Movement Disorder Society
Volume 27, Issue 10, pages 1308–1311, 1 September 2012
How to Cite
Reginold, W., Armstrong, M. J., Duff-Canning, S., Lang, A., Tang-Wai, D., Fox, S., Rothberg, B., Zadikoff, C., Kennedy, N., Gill, D., Eslinger, P., Mapstone, M., Chou, K., Persad, C., Litvan, I., Mast, B. and Marras, C. (2012), The pill questionnaire in a nondemented Parkinson's disease population. Mov. Disord., 27: 1308–1311. doi: 10.1002/mds.25124
Relevant conflicts of interest/financial disclosures: Connie Marras is supported by a New Investigator Award from the Canadian Institutes for Health Research.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 13 SEP 2012
- Article first published online: 1 AUG 2012
- Manuscript Accepted: 28 JUN 2012
- Manuscript Revised: 13 JUN 2012
- Manuscript Received: 17 JAN 2012
- Pill Questionnaire;
- Parkinson's disease;
- cognitive impairment;
We assessed the Pill Questionnaire as a screen for mild cognitive impairment in nondemented Parkinson's disease patients.
The relationship between ability to remember medications for Parkinson's disease in the Pill Questionnaire, mild cognitive impairment, and deficits on neuropsychological tests performed 2–3 weeks later blind to Pill Questionnaire results was assessed in movement disorders clinic patients.
In 109 subjects, inaccurate medication reporting on the Pill Questionnaire was associated with lower scores on the Montreal Cognitive Assessment, Scales for Outcomes in Parkinson's Disease–Cognition and with deficits in memory, attention, executive function-inhibitory control, processing speed, visuospatial function, and language. Inaccurate medication reporting was also associated with an adjusted odds ratio of 2.4 (95% CI, 0.91–5.88; P = .06) for mild cognitive impairment, with a specificity of 80% and sensitivity of 41%.
The Pill Questionnaire is neither sensitive nor specific enough to be used as the sole screening or diagnostic tool for mild cognitive impairment. However, inaccurate medication reporting is associated with deficits spanning many cognitive domains and should alert a clinician to a higher likelihood of cognitive impairment. © 2012 Movement Disorder Society