Relevant conflicts of interest/financial disclosures: Nothing to report.
Article first published online: 4 OCT 2012
Copyright © 2012 Movement Disorder Society
Volume 27, Issue 12, pages 1559–1563, October 2012
How to Cite
Fonoff, E. T., Campos, W. K., Mandel, M., Alho, E. J. L. and Teixeira, M. J. (2012), Bilateral subthalamic nucleus stimulation for generalized dystonia after bilateral pallidotomy. Mov. Disord., 27: 1559–1563. doi: 10.1002/mds.25127
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 18 OCT 2012
- Article first published online: 4 OCT 2012
- Manuscript Accepted: 13 JUL 2012
- Manuscript Revised: 21 JUN 2012
- Manuscript Received: 20 FEB 2012
- University of São Paulo School of Medicine, São Paulo, Brazil
- deep brain stimulation;
- subthalamic nucleus
Thalamotomies and pallidotomies were commonly performed before the deep brain stimulation (DBS) era. Although ablative procedures can lead to significant dystonia improvement, longer periods of analysis reveal disease progression and functional deterioration. Today, the same patients seek additional treatment possibilities.
Four patients with generalized dystonia who previously had undergone bilateral pallidotomy came to our service seeking additional treatment because of dystonic symptom progression. Bilateral subthalamic nucleus DBS (B-STN-DBS) was the treatment of choice. The patients were evaluated with the Burke–Fahn–Marsden Dystonia Rating Scale (BFMDRS) and the Unified Dystonia Rating Scale (UDRS) before and 2 years after surgery.
All patients showed significant functional improvement, averaging 65.3% in BFMDRS (P = .014) and 69.2% in UDRS (P = .025).
These results suggest that B-STN-DBS may be an interesting treatment option for generalized dystonia, even for patients who have already undergone bilateral pallidotomy. © 2012 Movement Disorder Society