Relevant conflicts of interest/financial disclosures: Nothing to report.
Article first published online: 13 NOV 2012
Copyright © 2012 Movement Disorder Society
Volume 27, Issue 13, pages 1679–1682, November 2012
How to Cite
Poletti, M., Perugi, G., Logi, C., Romano, A., Del Dotto, P., Ceravolo, R., Rossi, G., Pepe, P., Dell'Osso, L. and Bonuccelli, U. (2012), Dopamine agonists and delusional jealousy in Parkinson's disease: A cross-sectional prevalence study. Mov. Disord., 27: 1679–1682. doi: 10.1002/mds.25129
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 27 NOV 2012
- Article first published online: 13 NOV 2012
- Manuscript Accepted: 28 JUN 2012
- Manuscript Revised: 18 JUN 2012
- Manuscript Received: 20 OCT 2011
- Parkinson's disease;
- delusion of jealousy;
- dopamine agonists;
Delusional jealousy (DJ) has been described in patients with Parkinson's disease (PD) on dopaminergic therapy, but a role for dopaminergic therapy in DJ has not been established.
The current cross-sectional study on DJ investigated its association with dopaminergic therapies compared with their associations with hallucinations and its prevalence in PD patients. Eight hundred five consecutive patients with PD were enrolled between January 2009 and June 2010.
DJ was identified in 20 patients (2.48%) and hallucinations in 193 patients (23.98%). In the multivariate logistic regression analyses, dopamine agonists were significantly associated with DJ (odds ratio, 18.1; 95% CI, 3.0–infinity; P = .0002) but not with hallucinations (odds ratio, 0.73; 95% CI, 0.49–1.10; P = .133).
These findings suggest that dopamine agonist treatment represents a risk factor for DJ in PD independent of the presence of a dementing disorder, and the presence of this additional nonmotor side effect should be investigated in this clinical population. © 2012 Movement Disorder Society