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Head injury and Parkinson's disease: A population-based study§


  • Funding agencies: The study was supported by the Swedish Research Council (SIMSAM grant no. 80748301), the Swedish Parkinson Foundation, the Swedish Medical Society, the Swedish Society for Medical Research, the Swedish Brain Foundation, and the intramural research program of the National Institutes of Health, the National Institute of Environmental Health Sciences (Z01-ES-101986 and unmet need funding). The funding sources had no role in the design of the study or the decision to submit the manuscript for publication.

  • Relevant conflicts of interest/financial disclosures: None of the authors has a conflict of interest. The project was approved by the Regional Ethics Vetting Board in Stockholm.

  • §

    Full financial disclosures and author roles may be found in the online version of this article.



The epidemiological evidence on head injury and the risk of Parkinson's disease (PD) has been inconsistent.


We examined the relation between previous hospitalization for head injury and PD using a population-based nested case-control design based on the Swedish National Patient Register from 2001 until 2007, including 18,648 PD cases and 93,240 controls, randomly selected from the general population. Exposure was defined as hospitalization for head injury between 1987 and index date.


Overall, previous hospitalization resulting from head injury was associated with an increased risk of PD; this association appeared to be largely explained by head injuries experienced recently, especially within 1 year before PD ascertainment.


Our results do not provide convincing evidence for a causal relationship between head injury later in life and PD. © 2012 Movement Disorder Society