Funding agencies: The Spanish Health Research Agency and the Spanish Office of Science and Technology supported NEDICES.
Rate of cognitive decline in premotor Parkinson's disease: A prospective study (NEDICES)
Article first published online: 12 DEC 2012
Copyright © 2012 Movement Disorders Society
Volume 28, Issue 2, pages 161–168, February 2013
How to Cite
Sánchez-Ferro, Á., Benito-León, J., Louis, E. D., Mitchell, A. J., Molina-Arjona, J. A., Trincado, R., Villarejo, A. and Bermejo-Pareja, F. (2013), Rate of cognitive decline in premotor Parkinson's disease: A prospective study (NEDICES). Mov. Disord., 28: 161–168. doi: 10.1002/mds.25148
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 23 FEB 2013
- Article first published online: 12 DEC 2012
- Manuscript Accepted: 17 JUL 2012
- Manuscript Revised: 2 JUL 2012
- Manuscript Received: 4 FEB 2012
- cognitive function;
- Parkinson's disease;
- premotor symptoms;
- population-based study
Previous research has documented cognitive impairment in the early stages of Parkinson's disease (PD). It is not known when this decline starts or if decline progresses at an accelerated rate during the premotor period of the disorder. In this population-based prospective study of older people (≥65 years) from the Neurological Disorders in Central Spain (NEDICES) cohort, we compared the rates of cognitive decline in 3 groups: (1) non-PD elderly controls; (2) prevalent PD patients (those diagnosed with the disease at baseline, 1994–95); and (3) premotor PD subjects (those diagnosed with the disease at follow up, 1997–98, but not at baseline). A 37-item version of the Mini–Mental State Examination (37-MMSE) was administered in the 2 visits of the study. From 2487 participants (age, 72.8 ± 6.0 years), including 2429 controls, we recruited 21 premotor PD cases, and 37 prevalent PD cases. At baseline, the mean 37-MMSE score was 28.5 ± 4.7 in prevalent cases, 28.1 ± 4.6 in premotor cases, and 29.9 ± 5.0 in controls (P = .046). During the 3-year follow-up period, there was a significant score decline of 2.4 ± 4.6 points in prevalent cases versus 0.2 ± 4.1 points in premotor cases and 0.3 ± 4.0 points in controls (Kruskal–Wallis test, P = .03). In the NEDICES cohort, cognitive test scores of prevalent PD cases declined at a rate above and beyond that observed in premotor PD cases and in controls. The rate of cognitive decline in premotor PD and controls was similar. Our data suggest that a decline in global cognitive function does not occur in premotor PD. © 2012 Movement Disorder Society